Literature DB >> 23012990

[Fullerene C60 exhibits immunomodulatory activity during adjuvant-induced arthritis in rats].

L É Vesnina, T V Mamontova, M V Mikitiuk, N A Bobrova, L A Kutsenko, G A Iaroshenko, I P Kaĭdashev.   

Abstract

The effect of fullerene C60 (FC60) on the immune processes during experimental adjuvant-induced arthritis (AA) in rats has been studied. The results indicate the inhibitory action of FN60 during AA on cellular splenocyte proliferation, neutrophil phagocytic and oxygen-stimulatory activities in the NBT test, and humoral immune mechanisms involved in the production of antinuclear antibodies, formation of circulating immune complexes, and restoration of morphological structure of spleen. Taken together, these results allow FC60 to be considered as a new potential pharmacological agent that can realize its effects mainly through anti-inflammatory and immunomodulatory activity.

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Year:  2012        PMID： 23012990

Source DB:  PubMed          Journal:  Eksp Klin Farmakol        ISSN： 0869-2092


  2 in total

1.  C60 fullerene and its nanocomplexes with anticancer drugs modulate circulating phagocyte functions and dramatically increase ROS generation in transformed monocytes.

Authors:  Larysa M Skivka; Svitlana V Prylutska; Mariia P Rudyk; Nataliia M Khranovska; Ievgeniia V Opeida; Vasyl V Hurmach; Yuriy I Prylutskyy; Leonid F Sukhodub; Uwe Ritter
Journal:  Cancer Nanotechnol       Date:  2018-10-31

2.  Amelioration of Experimentally Induced Arthritis by Reducing Reactive Oxygen Species Production through the Intra-Articular Injection of Water-Soluble Fullerenol.

Authors:  Wen-Shuo Kuo; Chia-Tse Weng; Jian-Hua Chen; Chao-Liang Wu; Ai-Li Shiau; Jeng-Long Hsieh; Edmund Cheung So; Po-Ting Wu; Shih-Yao Chen
Journal:  Nanomaterials (Basel)       Date:  2019-06-23       Impact factor: 5.076
  2 in total

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