Literature DB >> 23012694

I-motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes.

John A Brazier1, Arti Shah, Geoffrey D Brown.   

Abstract

I-motif formation has been confirmed in a number of gene promoter sequences known to form G-quadruplex structures. I-motif formation can occur close to physiological temperature and pH for h-tert and PDGF-A. The i-motif structure formed by a HIF-1α promoter sequence shows unexpected stability near neutral pH.

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Year:  2012        PMID： 23012694     DOI： 10.1039/c2cc30863k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  29 in total

1.  Topological impact of noncanonical DNA structures on Klenow fragment of DNA polymerase.

Authors:  Shuntaro Takahashi; John A Brazier; Naoki Sugimoto
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-21       Impact factor: 11.205

2.  Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks.

Authors:  Rucha Kshirsagar; Krishnendu Khan; Mamata V Joshi; Ramakrishna V Hosur; K Muniyappa
Journal:  Biophys J       Date:  2017-05-23       Impact factor: 4.033

3.  Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression.

Authors:  Christine E Kaiser; Natalie A Van Ert; Prashansa Agrawal; Reena Chawla; Danzhou Yang; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2017-06-15       Impact factor: 15.419

4.  Analysis of putative quadruplex-forming sequences in fungal genomes: novel antifungal targets?

Authors:  Emily F Warner; Natália Bohálová; Václav Brázda; Zoë A E Waller; Stefan Bidula
Journal:  Microb Genom       Date:  2021-05

5.  The importance of loop length on the stability of i-motif structures.

Authors:  Sarah P Gurung; Christine Schwarz; James P Hall; Christine J Cardin; John A Brazier
Journal:  Chem Commun (Camb)       Date:  2015-04-04       Impact factor: 6.222

6.  Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences.

Authors:  Elisé P Wright; Henry A Day; Ali M Ibrahim; Jeethendra Kumar; Leo J E Boswell; Camille Huguin; Clare E M Stevenson; Klaus Pors; Zoë A E Waller
Journal:  Sci Rep       Date:  2016-12-22       Impact factor: 4.379

7.  The structure of an endogenous Drosophila centromere reveals the prevalence of tandemly repeated sequences able to form i-motifs.

Authors:  Miguel Garavís; María Méndez-Lago; Valérie Gabelica; Siobhan L Whitehead; Carlos González; Alfredo Villasante
Journal:  Sci Rep       Date:  2015-08-20       Impact factor: 4.379

8.  Distance-dependent duplex DNA destabilization proximal to G-quadruplex/i-motif sequences.

Authors:  Sebastian L B König; Julian L Huppert; Roland K O Sigel; Amanda C Evans
Journal:  Nucleic Acids Res       Date:  2013-06-14       Impact factor: 16.971

9.  The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.

Authors:  Samantha Kendrick; Hyun-Jin Kang; Mohammad P Alam; Manikandadas M Madathil; Prashansa Agrawal; Vijay Gokhale; Danzhou Yang; Sidney M Hecht; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2014-03-07       Impact factor: 15.419

10.  Re-evaluation of G-quadruplex propensity with G4Hunter.

Authors:  Amina Bedrat; Laurent Lacroix; Jean-Louis Mergny
Journal:  Nucleic Acids Res       Date:  2016-01-20       Impact factor: 16.971
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