OBJECTIVES: Identifying common clinical and environmental factors that influence newborn metabolic biomarkers will improve the utilization of metabolite panels for clinical diagnostic medicine. DESIGN AND METHODS: Environmental effects including gender, season of birth, gestational age, birth weight, feeding method and age at time of collection were evaluated for over 50 metabolites collected by the Iowa Neonatal Metabolic Screening Program on 221,788 newborns over a six year period. RESULTS: We replicated well known observations that low birth weight and preterm infants have higher essential amino acids and lower medium and long chain acylcarnitine levels than their term counterparts. Smaller, but still significant, differences were observed for gender and timing of sample collection, specifically the season in which the infant was born. Most intriguing were our findings of higher thyroid stimulating hormone in the winter months (P<1×10(-40)) which correlated with an increased false positive rate of congenital hypothyroidism in the winter (0.9%) compared to summer (0.6%). Previous studies, conducted globally, have identified an increased prevalence of suspected and confirmed cases of congenital hypothyroidism in the winter months. We found that the percentage of unresolved suspected cases were slightly higher in the winter (0.3% vs. 0.2%). CONCLUSIONS: We identified differences in metabolites by gestational age, birth weight, gender and season. Some are widely reported such as gestational age and birth weight, while others such as the effect of seasonality are not as well studied.
OBJECTIVES: Identifying common clinical and environmental factors that influence newborn metabolic biomarkers will improve the utilization of metabolite panels for clinical diagnostic medicine. DESIGN AND METHODS: Environmental effects including gender, season of birth, gestational age, birth weight, feeding method and age at time of collection were evaluated for over 50 metabolites collected by the Iowa Neonatal Metabolic Screening Program on 221,788 newborns over a six year period. RESULTS: We replicated well known observations that low birth weight and preterm infants have higher essential amino acids and lower medium and long chain acylcarnitine levels than their term counterparts. Smaller, but still significant, differences were observed for gender and timing of sample collection, specifically the season in which the infant was born. Most intriguing were our findings of higher thyroid stimulating hormone in the winter months (P<1×10(-40)) which correlated with an increased false positive rate of congenital hypothyroidism in the winter (0.9%) compared to summer (0.6%). Previous studies, conducted globally, have identified an increased prevalence of suspected and confirmed cases of congenital hypothyroidism in the winter months. We found that the percentage of unresolved suspected cases were slightly higher in the winter (0.3% vs. 0.2%). CONCLUSIONS: We identified differences in metabolites by gestational age, birth weight, gender and season. Some are widely reported such as gestational age and birth weight, while others such as the effect of seasonality are not as well studied.
Authors: Kelli K Ryckman; Caitlin J Smith; Laura L Jelliffe-Pawlowski; Allison M Momany; Stanton L Berberich; Jeffrey C Murray Journal: Hum Genet Date: 2014-05-22 Impact factor: 4.132
Authors: Steven Hawken; Malia S Q Murphy; Robin Ducharme; A Brianne Bota; Lindsay A Wilson; Wei Cheng; Ma-Am Joy Tumulak; Maria Melanie Liberty Alcausin; Ma Elouisa Reyes; Wenjuan Qiu; Beth K Potter; Julian Little; Mark Walker; Lin Zhang; Carmencita Padilla; Pranesh Chakraborty; Kumanan Wilson Journal: Gates Open Res Date: 2021-06-21
Authors: Scott P Oltman; Elizabeth E Rogers; Rebecca J Baer; Elizabeth A Jasper; James G Anderson; Martina A Steurer; Matthew S Pantell; Mark A Petersen; J Colin Partridge; Deborah Karasek; Kharah M Ross; Sky K Feuer; Linda S Franck; Larry Rand; John M Dagle; Kelli K Ryckman; Laura L Jelliffe-Pawlowski Journal: Pediatr Res Date: 2020-10-01 Impact factor: 3.756