| Literature DB >> 23010279 |
Arada Rojana-udomsart1, Chalermchai Mitrpant, Ian James, Campbell Witt, Merrilee Needham, Timothy Day, Lynette Kiers, Alastair Corbett, Patricia Martinez, Steve D Wilton, Frank L Mastaglia.
Abstract
We compared the carriage frequencies of HLA-DRB3 and its major alleles and of HLA-DRB4 and HLA-DRB5 in an Australian sIBM cohort and a population control group who had previously been genotyped for the HLA-DRB1*03:01 risk allele. There was a strong disease association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01. The carriage of HLA-DRB4 was found to be strongly protective and abrogated the risk effect of HLA-DRB1*03:01. The findings indicate that haplotypic combinations of alleles at the HLA-DRB1 and secondary HLA-DRB loci have important risk modifying effects in sIBM.Entities:
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Year: 2012 PMID： 23010279 DOI： 10.1016/j.jneuroim.2012.09.003
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478