BACKGROUND: Adults who were born with low birth weights are at increased risk of cardiovascular and metabolic conditions, including pregnancy complications. Low birth weight can result from intrauterine growth restriction, preterm birth or both. We examined the relation between preterm birth and pregnancy complications later in life. METHODS: We conducted a population-based cohort study in the province of Quebec involving 7405 women born preterm (554 < 32 weeks, 6851 at 32-36 weeks) and a matched cohort of 16 714 born at term between 1976 and 1995 who had a live birth or stillbirth between 1987 and 2008. The primary outcome measures were pregnancy complications (gestational diabetes, gestational hypertension, and preeclampsia or eclampsia). RESULTS: Overall, 19.9% of women born at less than 32 weeks, 13.2% born at 32-36 weeks and 11.7% born at term had at least 1 pregnancy complication at least once during the study period (p < 0.001). Women born small for gestational age (both term and preterm) had increased odds of having at least 1 pregnancy complication compared with women born at term and at appropriate weight for gestational age. After adjustment for various factors, including birth weight for gestational age, the odds of pregnancy complications associated with preterm birth was elevated by 1.95-fold (95% confidence interval [CI] 1.54-2.47) among women born before 32 weeks' gestation and 1.14-fold (95% CI 1.03-1.25) among those born at 32-36 weeks' gestation relative to women born at term. INTERPRETATION: Being born preterm, in addition to, and independent of, being small for gestational age, was associated with a significantly increased risk of later having pregnancy complications.
BACKGROUND: Adults who were born with low birth weights are at increased risk of cardiovascular and metabolic conditions, including pregnancy complications. Low birth weight can result from intrauterine growth restriction, preterm birth or both. We examined the relation between preterm birth and pregnancy complications later in life. METHODS: We conducted a population-based cohort study in the province of Quebec involving 7405 women born preterm (554 < 32 weeks, 6851 at 32-36 weeks) and a matched cohort of 16 714 born at term between 1976 and 1995 who had a live birth or stillbirth between 1987 and 2008. The primary outcome measures were pregnancy complications (gestational diabetes, gestational hypertension, and preeclampsia or eclampsia). RESULTS: Overall, 19.9% of women born at less than 32 weeks, 13.2% born at 32-36 weeks and 11.7% born at term had at least 1 pregnancy complication at least once during the study period (p < 0.001). Women born small for gestational age (both term and preterm) had increased odds of having at least 1 pregnancy complication compared with women born at term and at appropriate weight for gestational age. After adjustment for various factors, including birth weight for gestational age, the odds of pregnancy complications associated with preterm birth was elevated by 1.95-fold (95% confidence interval [CI] 1.54-2.47) among women born before 32 weeks' gestation and 1.14-fold (95% CI 1.03-1.25) among those born at 32-36 weeks' gestation relative to women born at term. INTERPRETATION: Being born preterm, in addition to, and independent of, being small for gestational age, was associated with a significantly increased risk of later having pregnancy complications.
Authors: Christine A Stone; Kylie A McLachlan; Jane L Halliday; Peter Wein; Christine Tippett Journal: Med J Aust Date: 2002-11-04 Impact factor: 7.738
Authors: Anders E B Aberg; Eva K Jönsson; Inger Eskilsson; Mona Landin-Olsson; Anders H Frid Journal: Acta Obstet Gynecol Scand Date: 2002-01 Impact factor: 3.636
Authors: Jennifer C Dempsey; Michelle A Williams; David A Luthy; Irvin Emanuel; Kirk Shy Journal: Am J Obstet Gynecol Date: 2003-08 Impact factor: 8.661
Authors: A Weichert; T M Weichert; R L Bergmann; W Henrich; K D Kalache; R Richter; J Neymeyer; K E Bergmann Journal: Geburtshilfe Frauenheilkd Date: 2015-08 Impact factor: 2.915
Authors: Barbara S E Verstraeten; J Keiko McCreary; Steven Weyers; Gerlinde A S Metz; David M Olson Journal: Biol Reprod Date: 2019-01-01 Impact factor: 4.285
Authors: Valerie A Luyckx; Norberto Perico; Marco Somaschini; Dario Manfellotto; Herbert Valensise; Irene Cetin; Umberto Simeoni; Karel Allegaert; Bjorn Egil Vikse; Eric A Steegers; Dwomoa Adu; Giovanni Montini; Giuseppe Remuzzi; Barry M Brenner Journal: Lancet Date: 2017-03-09 Impact factor: 79.321
Authors: Mariane Bertagnolli; Thuy Mai Luu; Adam James Lewandowski; Paul Leeson; Anne Monique Nuyt Journal: Curr Hypertens Rep Date: 2016-04 Impact factor: 5.369