BACKGROUND: Being born small for gestational age (SGA) (birth weight <10th percentile) is connected to decreased white matter (WM) integrity in newborns and increased prevalence of psychiatric symptoms in adulthood. The aims of this study were to investigate whether being born SGA at term affects WM integrity in young adulthood and to explore possible relationships between fractional anisotropy (FA) and pre- and perinatal factors and cognitive and psychiatric outcomes in adulthood in SGA and controls. METHODS: Diffusion tensor imaging and tract-based spatial statistics were conducted to test for voxelwise differences in FA in SGAs (n = 46) and controls (n = 57) at 18-22 y. RESULTS: As compared with controls SGAs had reduced FA in ventral association tracts and internal/external capsules. In the SGAs, no relationship was found between FA and intrauterine head growth in the third trimester, although total intelligence quotient was negatively correlated to FA. In controls, a positive correlation was found between FA and brain growth in the third trimester and maternal smoking. No relationship was found between FA and psychiatric measures in SGAs or controls. CONCLUSION: These results demonstrate that being born SGA leads to reduced WM integrity in adulthood, and suggest that different factors modulate the development of WM in SGA and control groups.
BACKGROUND: Being born small for gestational age (SGA) (birth weight <10th percentile) is connected to decreased white matter (WM) integrity in newborns and increased prevalence of psychiatric symptoms in adulthood. The aims of this study were to investigate whether being born SGA at term affects WM integrity in young adulthood and to explore possible relationships between fractional anisotropy (FA) and pre- and perinatal factors and cognitive and psychiatric outcomes in adulthood in SGA and controls. METHODS: Diffusion tensor imaging and tract-based spatial statistics were conducted to test for voxelwise differences in FA in SGAs (n = 46) and controls (n = 57) at 18-22 y. RESULTS: As compared with controls SGAs had reduced FA in ventral association tracts and internal/external capsules. In the SGAs, no relationship was found between FA and intrauterine head growth in the third trimester, although total intelligence quotient was negatively correlated to FA. In controls, a positive correlation was found between FA and brain growth in the third trimester and maternal smoking. No relationship was found between FA and psychiatric measures in SGAs or controls. CONCLUSION: These results demonstrate that being born SGA leads to reduced WM integrity in adulthood, and suggest that different factors modulate the development of WM in SGA and control groups.
Authors: Katja Franke; Bea R H Van den Bergh; Susanne R de Rooij; Nasim Kroegel; Peter W Nathanielsz; Florian Rakers; Tessa J Roseboom; Otto W Witte; Matthias Schwab Journal: Neurosci Biobehav Rev Date: 2020-01-28 Impact factor: 8.989
Authors: Kristine B Walhovd; Anders M Fjell; Timothy T Brown; Joshua M Kuperman; Yoonho Chung; Donald J Hagler; J Cooper Roddey; Matthew Erhart; Connor McCabe; Natacha Akshoomoff; David G Amaral; Cinnamon S Bloss; Ondrej Libiger; Nicholas J Schork; Burcu F Darst; B J Casey; Linda Chang; Thomas M Ernst; Jean Frazier; Jeffrey R Gruen; Walter E Kaufmann; Sarah S Murray; Peter van Zijl; Stewart Mostofsky; Anders M Dale Journal: Proc Natl Acad Sci U S A Date: 2012-11-19 Impact factor: 11.205
Authors: Asta Kristine Håberg; Tommy Arild Hammer; Kjell Arne Kvistad; Jana Rydland; Tomm B Müller; Live Eikenes; Mari Gårseth; Lars Jacob Stovner Journal: PLoS One Date: 2016-03-07 Impact factor: 3.240
Authors: Michael Fanous; Megan P Caputo; Young Jae Lee; Laurie A Rund; Catherine Best-Popescu; Mikhail E Kandel; Rodney W Johnson; Tapas Das; Matthew J Kuchan; Gabriel Popescu Journal: PLoS One Date: 2020-11-19 Impact factor: 3.240