Literature DB >> 23006748

Targeting essential genes in Salmonella enterica serovar typhimurium with antisense peptide nucleic acid.

Muhammad A Soofi1, Mohamed N Seleem.   

Abstract

We investigated the capability of antisense peptide nucleic acids (PNAs) conjugated to the (KFF)(3)K cell-penetrating peptide to target possible essential genes (ligA, rpoA, rpoD, engA, tsf, and kdtA) in Salmonella enterica serovar Typhimurium and inhibit bacterial growth in vitro and in cell culture. All targeted PNA-based gene inhibition has shown great potency in gene expression inhibition in a sequence-specific and dose-dependent manner at micromolar concentrations. Among tested PNAs, the anti-rpoA and -rpoD PNAs showed the greatest potency.

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Year:  2012        PMID： 23006748      PMCID： PMC3497187          DOI： 10.1128/AAC.01437-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Antisense inhibition of gene expression and growth in gram-negative bacteria by cell-penetrating peptide conjugates of peptide nucleic acids targeted to rpoD gene.

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Journal:  Biomaterials       Date:  2011-10-14       Impact factor: 12.479

2.  Cell permeabilization and uptake of antisense peptide-peptide nucleic acid (PNA) into Escherichia coli.

Authors:  Magdalena Eriksson; Peter E Nielsen; Liam Good
Journal:  J Biol Chem       Date:  2001-12-05       Impact factor: 5.157

3.  Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.

Authors:  M McClelland; K E Sanderson; J Spieth; S W Clifton; P Latreille; L Courtney; S Porwollik; J Ali; M Dante; F Du; S Hou; D Layman; S Leonard; C Nguyen; K Scott; A Holmes; N Grewal; E Mulvaney; E Ryan; H Sun; L Florea; W Miller; T Stoneking; M Nhan; R Waterston; R K Wilson
Journal:  Nature       Date:  2001-10-25       Impact factor: 49.962

4.  Inhibition of gene expression and growth by antisense peptide nucleic acids in a multiresistant beta-lactamase-producing Klebsiella pneumoniae strain.

Authors:  Prathiba Kurupati; Kevin Shyong Wei Tan; Gamini Kumarasinghe; Chit Laa Poh
Journal:  Antimicrob Agents Chemother       Date:  2006-12-11       Impact factor: 5.191

5.  Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium.

Authors:  Heather K Lamb; Paul Thompson; Catherine Elliott; Ian G Charles; Jamie Richards; Michael Lockyer; Nicholas Watkins; Charles Nichols; David K Stammers; Clive R Bagshaw; Alan Cooper; Alastair R Hawkins
Journal:  Protein Sci       Date:  2007-09-28       Impact factor: 6.725

6.  Inhibition of intracellular growth of Salmonella enterica serovar Typhimurium in tissue culture by antisense peptide-phosphorodiamidate morpholino oligomer.

Authors:  Georgi M Mitev; Brett L Mellbye; Patrick L Iversen; Bruce L Geller
Journal:  Antimicrob Agents Chemother       Date:  2009-07-06       Impact factor: 5.191

7.  The translation start codon region is sensitive to antisense PNA inhibition in Escherichia coli.

Authors:  Rikard Dryselius; Satish Kumar Aswasti; Gunaratna K Rajarao; Peter E Nielsen; Liam Good
Journal:  Oligonucleotides       Date:  2003

Review 8.  An introduction to peptide nucleic acid.

Authors:  P E Nielsen; M Egholm
Journal:  Curr Issues Mol Biol       Date:  1999       Impact factor: 2.081

9.  Targeting RNA polymerase primary σ70 as a therapeutic strategy against methicillin-resistant Staphylococcus aureus by antisense peptide nucleic acid.

Authors:  Hui Bai; Guojun Sang; Yu You; Xiaoyan Xue; Ying Zhou; Zheng Hou; Jingru Meng; Xiaoxing Luo
Journal:  PLoS One       Date:  2012-01-10       Impact factor: 3.240

10.  Hitting bacteria at the heart of the central dogma: sequence-specific inhibition.

Authors:  Louise Carøe Vohlander Rasmussen; Hans Uffe Sperling-Petersen; Kim Kusk Mortensen
Journal:  Microb Cell Fact       Date:  2007-08-10       Impact factor: 5.328
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  9 in total

1.  Targeting listeria monocytogenes rpoA and rpoD genes using peptide nucleic acids.

Authors:  Ruba A Alajlouni; Mohamed N Seleem
Journal:  Nucleic Acid Ther       Date:  2013-07-16       Impact factor: 5.486

2.  Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria.

Authors:  Kristen A Eller; Thomas R Aunins; Colleen M Courtney; Jocelyn K Campos; Peter B Otoupal; Keesha E Erickson; Nancy E Madinger; Anushree Chatterjee
Journal:  Commun Biol       Date:  2021-03-12

3.  Impact of different cell penetrating peptides on the efficacy of antisense therapeutics for targeting intracellular pathogens.

Authors:  Mostafa F N Abushahba; Haroon Mohammad; Shankar Thangamani; Asmaa A A Hussein; Mohamed N Seleem
Journal:  Sci Rep       Date:  2016-02-10       Impact factor: 4.379

Review 4.  Antibacterial Peptide Nucleic Acids-Facts and Perspectives.

Authors:  Monika Wojciechowska; Marcin Równicki; Adam Mieczkowski; Joanna Miszkiewicz; Joanna Trylska
Journal:  Molecules       Date:  2020-01-28       Impact factor: 4.411

5.  Potentiating the Anti-Tuberculosis Efficacy of Peptide Nucleic Acids through Combinations with Permeabilizing Drugs.

Authors:  Karishma Berta Cotta; Saptarshi Ghosh; Sarika Mehra
Journal:  Microbiol Spectr       Date:  2022-02-16

6.  Repurposing Clinical Molecule Ebselen to Combat Drug Resistant Pathogens.

Authors:  Shankar Thangamani; Waleed Younis; Mohamed N Seleem
Journal:  PLoS One       Date:  2015-07-29       Impact factor: 3.240

7.  A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii.

Authors:  Mohamed F Mohamed; Anna Brezden; Haroon Mohammad; Jean Chmielewski; Mohamed N Seleem
Journal:  Sci Rep       Date:  2017-07-31       Impact factor: 4.379

8.  Targeting Multidrug-resistant Staphylococci with an anti-rpoA Peptide Nucleic Acid Conjugated to the HIV-1 TAT Cell Penetrating Peptide.

Authors:  Mostafa Fn Abushahba; Haroon Mohammad; Mohamed N Seleem
Journal:  Mol Ther Nucleic Acids       Date:  2016-07-19       Impact factor: 10.183

Review 9.  Peptide nucleic acids: Advanced tools for biomedical applications.

Authors:  Anjali Gupta; Anuradha Mishra; Nidhi Puri
Journal:  J Biotechnol       Date:  2017-07-29       Impact factor: 3.307
  9 in total

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