Literature DB >> 23006322

Defending the cornea with antibacterial fragments of keratin.

Michael Zasloff1.   

Abstract

In addition to its role in refraction, the cornea forms a barrier between the eye and environmental and infectious insults. Corneal infections are surprisingly rare, suggesting that multiple aspects of the immune system are at play in mediating protection. In this issue of the JCI, Tam et al. describe the unexpected role of a structural protein, cytokeratin 6A, in this process.

Entities:  

Year:  2012        PMID： 23006322      PMCID： PMC3461931          DOI： 10.1172/JCI65380

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  9 in total

1.  Antimicrobial peptides of multicellular organisms.

Authors:  Michael Zasloff
Journal:  Nature       Date:  2002-01-24       Impact factor: 49.962

2.  Decreased tear lipocalin concentration in patients with meibomian gland dysfunction.

Authors:  M Yamada; H Mochizuki; M Kawai; K Tsubota; T J Bryce
Journal:  Br J Ophthalmol       Date:  2005-07       Impact factor: 4.638

3.  Influence of wall teichoic acid on lysozyme resistance in Staphylococcus aureus.

Authors:  Agnieszka Bera; Raja Biswas; Silvia Herbert; Emir Kulauzovic; Christopher Weidenmaier; Andreas Peschel; Friedrich Götz
Journal:  J Bacteriol       Date:  2006-11-03       Impact factor: 3.490

4.  In vitro evidence of involvement of the epithelial y+ transporter in β-defensin production on the ocular surface.

Authors:  Kristin Jäger; Andrea Nielitz; Fabian Garreis; Saadettin Sel; Heike Nave; Friedrich P Paulsen
Journal:  Ann Anat       Date:  2011-10-14       Impact factor: 2.698

5.  Pepsin-mediated processing of the cytoplasmic histone H2A to strong antimicrobial peptide buforin I.

Authors:  H S Kim; H Yoon; I Minn; C B Park; W T Lee; M Zasloff; S C Kim
Journal:  J Immunol       Date:  2000-09-15       Impact factor: 5.422

Review 6.  Functions of ocular surface mucins in health and disease.

Authors:  Flavio Mantelli; Pablo Argüeso
Journal:  Curr Opin Allergy Clin Immunol       Date:  2008-10

7.  Cytokeratins mediate epithelial innate defense through their antimicrobial properties.

Authors:  Connie Tam; James J Mun; David J Evans; Suzanne M J Fleiszig
Journal:  J Clin Invest       Date:  2012-09-24       Impact factor: 14.808

Review 8.  The role of antimicrobial peptides at the ocular surface.

Authors:  Alison M McDermott
Journal:  Ophthalmic Res       Date:  2008-12-20       Impact factor: 2.892

9.  Topical application of FTY720 and cyclosporin A prolong corneal graft survival in mice.

Authors:  Yong Liu; Jingjing Jiang; He Xiao; Xiaokui Wang; Yan Li; Yubo Gong; Dajiang Wang; Yifei Huang
Journal:  Mol Vis       Date:  2012-03-09       Impact factor: 2.367
  9 in total
  3 in total

Review 1.  Cornea and ocular surface disease: application of cutting-edge optometric research.

Authors:  Danielle M Robertson; Larry J Alexander; Joseph A Bonanno; Suzanne M J Fleiszig; Nancy McNamara
Journal:  Optom Vis Sci       Date:  2014-04       Impact factor: 1.973

2.  Why does the healthy cornea resist Pseudomonas aeruginosa infection?

Authors:  David J Evans; Suzanne M J Fleiszig
Journal:  Am J Ophthalmol       Date:  2013-04-17       Impact factor: 5.258

Review 3.  Epithelial Intermediate Filaments: Guardians against Microbial Infection?

Authors:  Florian Geisler; Rudolf E Leube
Journal:  Cells       Date:  2016-06-27       Impact factor: 6.600
  3 in total

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