Literature DB >> 23005273

Multistability with a metastable mixed state.

Kim Sneppen1, Namiko Mitarai.   

Abstract

Complex dynamical systems often show multiple metastable states. In macroevolution, such behavior is suggested by punctuated equilibrium and discrete geological epochs. In molecular biology, bistability is found in epigenetics and in the many mutually exclusive states that a human cell can take. Sociopolitical systems can be single-party regimes or a pluralism of balancing political fractions. To introduce multistability, we suggest a model system of D mutually exclusive microstates that battle for dominance in a large system. Assuming one common intermediate state, we obtain D+1 metastable macrostates for the system, one of which is a self-reinforced mixture of all D+1 microstates. Robustness of this metastable mixed state increases with diversity D.

Entities:  

Year:  2012        PMID: 23005273     DOI: 10.1103/PhysRevLett.109.100602

Source DB:  PubMed          Journal:  Phys Rev Lett        ISSN: 0031-9007            Impact factor:   9.161


  5 in total

1.  Epigenomics in 3D: importance of long-range spreading and specific interactions in epigenomic maintenance.

Authors:  Daniel Jost; Cédric Vaillant
Journal:  Nucleic Acids Res       Date:  2018-03-16       Impact factor: 16.971

2.  Quantifying epigenetic stability with minimum action paths.

Authors:  Amogh Sood; Bin Zhang
Journal:  Phys Rev E       Date:  2020-06       Impact factor: 2.529

3.  Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System.

Authors:  Beata Hat; Marek Kochańczyk; Marta N Bogdał; Tomasz Lipniacki
Journal:  PLoS Comput Biol       Date:  2016-02-29       Impact factor: 4.475

4.  Basin stability measure of different steady states in coupled oscillators.

Authors:  Sarbendu Rakshit; Bidesh K Bera; Soumen Majhi; Chittaranjan Hens; Dibakar Ghosh
Journal:  Sci Rep       Date:  2017-04-05       Impact factor: 4.379

5.  Quantifying the Stability of Coupled Genetic and Epigenetic Switches With Variational Methods.

Authors:  Amogh Sood; Bin Zhang
Journal:  Front Genet       Date:  2021-01-22       Impact factor: 4.599

  5 in total

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