| Literature DB >> 23002902 |
Justin J Omolo1, Vinesh Maharaj, Dashnie Naidoo, Thomas Klimkait, Hamisi M Malebo, Samwel Mtullu, Herbert V M Lyaruu, Charles B de Koning.
Abstract
Two new anti-HIV xanthones, 6,7,11-trihydroxy-10-methoxy-9-(7-methoxy-3-methyl-1-oxoisochroman-5-yl)-2-methyl-12-oxo-12H-benzo[b]xanthene-4-carboxylic acid (1) and 6,7-dihydroxy-10,11-dimethoxy-9-(7-methoxy-3-methyl-1-oxoisochroman-5-yl)-2-methyl-12-oxo-12H-benzo[b]xanthene-4-carboxylic acid (2), and a new hexadecahydrochrysen-3-ol (3) were isolated from the tubers of Pyrenacantha kaurabassana. Compounds 1 and 2 showed moderate anti-HIV activity when tested in the deCIPhR assay on HIV virus type NL4-3, with IC₅₀ values of 21 and 2 μg/mL, respectively.Mesh：
Substances：
Year: 2012 PMID： 23002902 DOI： 10.1021/np300255r
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050