Literature DB >> 2300204

Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils.

T Kodama1, M Freeman, L Rohrer, J Zabrecky, P Matsudaira, M Krieger.   

Abstract

The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis. The trimeric structure of the bovine type I scavenger receptor, deduced by complementary DNA cloning, contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. This stalk structure, composed of an alpha-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein.

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Year:  1990        PMID： 2300204     DOI： 10.1038/343531a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  190 in total

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