Literature DB >> 23001909

Multicompartment intracellular self-expanding nanogel for targeted delivery of drug cocktail.

Remant Bahadur K C1, Peisheng Xu.   

Abstract

A nano cocktail, NCPD, fabricated from a pH and redox dual responsive polymer shows a multicompartment structure. The NCPD nanogel is stable in physiological environments while intracellular spontaneous swelling and fast releasing its payload. NCPD displays much stronger synergism than its free drug counterpart, which suggests that NCPD could greatly attenuate the side effects of drug cocktails while boosting synergistic anticancer effects.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23001909     DOI： 10.1002/adma.201202687

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  16 in total

1.  Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery.

Authors:  Huacheng He; Alexander W Cattran; Tu Nguyen; Anna-Liisa Nieminen; Peisheng Xu
Journal:  Biomaterials       Date:  2014-08-22       Impact factor: 12.479

2.  Redox Potential-Sensitive N-Acetyl Cysteine-Prodrug Nanoparticles Inhibit the Activation of Microglia and Improve Neuronal Survival.

Authors:  Eleni Markoutsa; Peisheng Xu
Journal:  Mol Pharm       Date:  2017-04-04       Impact factor: 4.939

3.  Matrix Metalloproteinase-9-Responsive Nanogels for Proximal Surface Conversion and Activated Cellular Uptake.

Authors:  Mallory R Gordon; Bo Zhao; Francesca Anson; Ann Fernandez; Khushboo Singh; Celia Homyak; Mine Canakci; Richard W Vachet; S Thayumanavan
Journal:  Biomacromolecules       Date:  2018-02-08       Impact factor: 6.988

4.  Repurposing disulfiram for cancer therapy via targeted nanotechnology through enhanced tumor mass penetration and disassembly.

Authors:  Huacheng He; Eleni Markoutsa; Jing Li; Peisheng Xu
Journal:  Acta Biomater       Date:  2017-12-30       Impact factor: 8.947

5.  A bioactivatable self-quenched nanogel for targeted photodynamic therapy.

Authors:  Huacheng He; Anna-Liisa Nieminen; Peisheng Xu
Journal:  Biomater Sci       Date:  2019-10-02       Impact factor: 6.843

6.  Dual-drug loaded nanoneedles with targeting property for efficient cancer therapy.

Authors:  Xiangrui Yang; Shichao Wu; Wanyi Xie; Anran Cheng; Lichao Yang; Zhenqing Hou; Xin Jin
Journal:  J Nanobiotechnology       Date:  2017-12-19       Impact factor: 10.435

7.  Biodistribution Analysis of NIR-Labeled Nanogels Using in Vivo FMT Imaging in Triple Negative Human Mammary Carcinoma Models.

Authors:  Mallory R Gordon; Jiaming Zhuang; Judy Ventura; Longyu Li; Kishore Raghupathi; S Thayumanavan
Journal:  Mol Pharm       Date:  2018-02-12       Impact factor: 4.939

8.  Gold Nanosphere Gated Mesoporous Silica Nanoparticle Responsive to Near-Infrared Light and Redox Potential as a Theranostic Platform for Cancer Therapy.

Authors:  Bei Cheng; Huacheng He; Tao Huang; Stuart S Berr; Jiang He; Daping Fan; Jiajia Zhang; Peisheng Xu
Journal:  J Biomed Nanotechnol       Date:  2016-03       Impact factor: 4.099

9.  Cancer cell-selective killing polymer/copper combination.

Authors:  Huacheng He; Diego Altomare; Ufuk Ozer; Hanwen Xu; Kim Creek; Hexin Chen; Peisheng Xu
Journal:  Biomater Sci       Date:  2016-01       Impact factor: 6.843

10.  Enhanced Photothermal Therapy through the In Situ Activation of a Temperature and Redox Dual-Sensitive Nanoreservoir of Triptolide.

Authors:  Hai-Jun Liu; Mingming Wang; Xiangxiang Hu; Shanshan Shi; Peisheng Xu
Journal:  Small       Date:  2020-08-14       Impact factor: 13.281
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