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Literature DB >> 23001408

May the truth be with you: lubiprostone as EP receptor agonist/ClC-2 internalizing "inhibitor".

Yasutada Akiba, Jonathan D Kaunitz.

Abstract

Entities: Chemical Gene

Mesh：

Substances：
Lubiprostone
Alprostadil

Year: 2012 PMID： 23001408 DOI： 10.1007/s10620-012-2410-2

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

× No keyword cloud information.

32 in total

1. Distribution of ClC-2 chloride channel in rat and human epithelial tissues.

Authors: Joanna Lipecka; Moëz Bali; Annick Thomas; Pascale Fanen; Aleksander Edelman; Janine Fritsch
Journal: Am J Physiol Cell Physiol Date: 2002-04 Impact factor: 4.249

2. Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by a direct effect of intracellular chloride.

Authors: Marcelo Catalán; María Isabel Niemeyer; L Pablo Cid; Francisco V Sepúlveda
Journal: Gastroenterology Date: 2004-04 Impact factor: 22.682

Review 3. CLC chloride channels and transporters.

Authors: Thomas J Jentsch; Ioana Neagoe; Olaf Scheel
Journal: Curr Opin Neurobiol Date: 2005-06 Impact factor: 6.627

Review 4. ClC and CFTR chloride channel gating.

Authors: J K Foskett
Journal: Annu Rev Physiol Date: 1998 Impact factor: 19.318

5. Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers.

Authors: Michael Camilleri; Adil E Bharucha; Ryuji Ueno; Duane Burton; George M Thomforde; Kari Baxter; Sanna McKinzie; Alan R Zinsmeister
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2006-05 Impact factor: 4.052

6. Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic fibrosis airway cells.

Authors: E M Schwiebert; L P Cid-Soto; D Stafford; M Carter; C J Blaisdell; P L Zeitlin; W B Guggino; G R Cutting
Journal: Proc Natl Acad Sci U S A Date: 1998-03-31 Impact factor: 11.205

7. Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models.

Authors: Anselm A Zdebik; John E Cuffe; Marko Bertog; Christoph Korbmacher; Thomas J Jentsch
Journal: J Biol Chem Date: 2004-03-07 Impact factor: 5.157

8. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents.

Authors: John Cuppoletti; Danuta H Malinowska; Kirti P Tewari; Qiu-Ju Li; Ann M Sherry; Myra L Patchen; Ryuji Ueno
Journal: Am J Physiol Cell Physiol Date: 2004-06-22 Impact factor: 4.249

9. Long-term safety and effectiveness of lubiprostone, a chloride channel (ClC-2) activator, in patients with chronic idiopathic constipation.

Authors: Anthony J Lembo; John F Johanson; Henry P Parkman; Satish S Rao; Philip B Miner; Ryuji Ueno
Journal: Dig Dis Sci Date: 2011-07-19 Impact factor: 3.199

May the truth be with you: lubiprostone as EP receptor agonist/ClC-2 internalizing "inhibitor".

1. Distribution of ClC-2 chloride channel in rat and human epithelial tissues.

2. Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by a direct effect of intracellular chloride.

Review 3. CLC chloride channels and transporters.

Review 4. ClC and CFTR chloride channel gating.

5. Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers.

6. Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic fibrosis airway cells.

7. Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models.

8. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents.

9. Long-term safety and effectiveness of lubiprostone, a chloride channel (ClC-2) activator, in patients with chronic idiopathic constipation.

10. Lubiprostone stimulates duodenal bicarbonate secretion in rats.

Review 1. Lubiprostone in constipation: clinical evidence and place in therapy.

2. Receptor-mediated activation of CFTR via prostaglandin signaling pathways in the airway.

Review 3. Luminally Acting Agents for Constipation Treatment: A Review Based on Literatures and Patents.

4. Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action.