INTRODUCTION: Neurofibromatosis type 1 (NF1), one of the most common neurocutaneous disorders, is a multisystemic disease associated with tumors in any organ of the body, especially in the central nervous system and also the peripheral nervous system. Pilocytic astrocytomas have been described in almost all intracranial regions in patients with NF1. However, only a few patients with NF1 and tumor of the corpus callosum have been reported to date. MATERIAL AND METHODS: An 11-year-old white Spanish boy was evaluated due to a family history of NF1 and low performance test scores in school. He was studied from the neurological and intellectual level points of view. RESULTS: Magnetic resonance (MR) study revealed a tumor in the anterior-middle portion of the corpus callosum and a Wechsler Intelligence Scale for Children-Revised showed verbal IQ of 92, a performance IQ of 108, and a total IQ of 100. In addition, he showed attention deficit and hyperactivity disorder. CONCLUSIONS: Tumors of corpus callosum in patients with NF1 are very uncommon. The patient presented in this paper consulted due to family history of NF1, progressive hyperactivity, and below average school performance. The MR study showed tumor in the corpus callosum. Tumor histology was not investigated.
INTRODUCTION:Neurofibromatosis type 1 (NF1), one of the most common neurocutaneous disorders, is a multisystemic disease associated with tumors in any organ of the body, especially in the central nervous system and also the peripheral nervous system. Pilocytic astrocytomas have been described in almost all intracranial regions in patients with NF1. However, only a few patients with NF1 and tumor of the corpus callosum have been reported to date. MATERIAL AND METHODS: An 11-year-old white Spanish boy was evaluated due to a family history of NF1 and low performance test scores in school. He was studied from the neurological and intellectual level points of view. RESULTS: Magnetic resonance (MR) study revealed a tumor in the anterior-middle portion of the corpus callosum and a Wechsler Intelligence Scale for Children-Revised showed verbal IQ of 92, a performance IQ of 108, and a total IQ of 100. In addition, he showed attention deficit and hyperactivity disorder. CONCLUSIONS:Tumors of corpus callosum in patients with NF1 are very uncommon. The patient presented in this paper consulted due to family history of NF1, progressive hyperactivity, and below average school performance. The MR study showed tumor in the corpus callosum. Tumor histology was not investigated.
Authors: E C Dubovsky; T N Booth; G Vezina; C A Samango-Sprouse; K M Palmer; C O Brasseux Journal: AJNR Am J Neuroradiol Date: 2001-01 Impact factor: 3.825
Authors: Ignacio Pascual-Castroviejo; Samuel Ignacio Pascual-Pascual; Juan Viaño; Ramón Velázquez-Fragua; Fernando Carceller-Benito; Manuel Gutiérrez-Molina; Carmen Morales-Bastos Journal: Rev Neurol Date: 2010-04-16 Impact factor: 0.870
Authors: Ludwine Messiaen; Suxia Yao; Hilde Brems; Tom Callens; Achara Sathienkijkanchai; Ellen Denayer; Emily Spencer; Pamela Arn; Dusica Babovic-Vuksanovic; Carolyn Bay; Gary Bobele; Bruce H Cohen; Luis Escobar; Deborah Eunpu; Theresa Grebe; Robert Greenstein; Rachel Hachen; Mira Irons; David Kronn; Edmond Lemire; Kathleen Leppig; Cynthia Lim; Marie McDonald; Vinodh Narayanan; Amy Pearn; Robert Pedersen; Berkley Powell; Lawrence R Shapiro; David Skidmore; David Tegay; Heidi Thiese; Elaine H Zackai; Raymon Vijzelaar; Koji Taniguchi; Toranoshin Ayada; Fuyuki Okamoto; Akihiko Yoshimura; Annabel Parret; Bruce Korf; Eric Legius Journal: JAMA Date: 2009-11-18 Impact factor: 56.272