Literature DB >> 23000954

Emerging themes in SecA2-mediated protein export.

Meghan E Feltcher1, Miriam Braunstein.   

Abstract

The conserved general secretion (Sec) pathway carries out most protein export in bacteria and is powered by the essential ATPase SecA. Interestingly, mycobacteria and some Gram-positive bacteria possess two SecA proteins: SecA1 and SecA2. In these species, SecA1 is responsible for exporting most proteins, whereas SecA2 exports only a subset of substrates and is implicated in virulence. However, despite the impressive body of knowledge about the canonical SecA1, less is known concerning SecA2 function. Here, we review our current understanding of the different types of SecA2 systems and outline future directions for their study.

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Year:  2012        PMID： 23000954      PMCID： PMC4620680          DOI： 10.1038/nrmicro2874

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN： 1740-1526            Impact factor:   60.633


  125 in total

1.  A molecular switch in SecA protein couples ATP hydrolysis to protein translocation.

Authors:  S Karamanou; E Vrontou; G Sianidis; C Baud; T Roos; A Kuhn; A S Politou; A Economou
Journal:  Mol Microbiol       Date:  1999-12       Impact factor: 3.501

2.  Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function.

Authors:  G Sianidis; S Karamanou; E Vrontou; K Boulias; K Repanas; N Kyrpides; A S Politou; A Economou
Journal:  EMBO J       Date:  2001-03-01       Impact factor: 11.598

Review 3.  Mechanisms and principles of N-linked protein glycosylation.

Authors:  Flavio Schwarz; Markus Aebi
Journal:  Curr Opin Struct Biol       Date:  2011-10       Impact factor: 6.809

4.  Identification of dipeptide repeats and a cell wall sorting signal in the fimbriae-associated adhesin, Fap1, of Streptococcus parasanguis.

Authors:  H Wu; P M Fives-Taylor
Journal:  Mol Microbiol       Date:  1999-12       Impact factor: 3.501

5.  Molecular characterization of the surface layer proteins from Clostridium difficile.

Authors:  E Calabi; S Ward; B Wren; T Paxton; M Panico; H Morris; A Dell; G Dougan; N Fairweather
Journal:  Mol Microbiol       Date:  2001-06       Impact factor: 3.501

6.  Clostridium difficile has two parallel and essential Sec secretion systems.

Authors:  Robert P Fagan; Neil F Fairweather
Journal:  J Biol Chem       Date:  2011-06-09       Impact factor: 5.157

7.  Characterization of a cell surface protein of Clostridium difficile with adhesive properties.

Authors:  A J Waligora; C Hennequin; P Mullany; P Bourlioux; A Collignon; T Karjalainen
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

8.  Characterization of Streptococcus gordonii SecA2 as a paralogue of SecA.

Authors:  Barbara A Bensing; Paul M Sullam
Journal:  J Bacteriol       Date:  2009-04-10       Impact factor: 3.490

9.  The Accessory SecA2 System of Mycobacteria Requires ATP Binding and the Canonical SecA1.

Authors:  Nathan W Rigel; Henry S Gibbons; Jessica R McCann; Justin A McDonough; Sherry Kurtz; Miriam Braunstein
Journal:  J Biol Chem       Date:  2009-02-23       Impact factor: 5.157

10.  Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG.

Authors:  Shanmugalakshmi Sadagopal; Miriam Braunstein; Cynthia C Hager; Jie Wei; Alexandria K Daniel; Markian R Bochan; Ian Crozier; Nathaniel E Smith; Hiriam O Gates; Louise Barnett; Luc Van Kaer; James O Price; Timothy S Blackwell; Spyros A Kalams; Douglas S Kernodle
Journal:  PLoS One       Date:  2009-05-13       Impact factor: 3.240
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  38 in total

1.  Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.

Authors:  Stephanie Swanson; Thomas R Ioerger; Nathan W Rigel; Brittany K Miller; Miriam Braunstein; James C Sacchettini
Journal:  J Bacteriol       Date:  2015-12-14       Impact factor: 3.490

Review 2.  Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface.

Authors:  M Sloan Siegrist; Benjamin M Swarts; Douglas M Fox; Shion An Lim; Carolyn R Bertozzi
Journal:  FEMS Microbiol Rev       Date:  2015-01-23       Impact factor: 16.408

3.  Label-free Quantitative Proteomics Reveals a Role for the Mycobacterium tuberculosis SecA2 Pathway in Exporting Solute Binding Proteins and Mce Transporters to the Cell Wall.

Authors:  Meghan E Feltcher; Harsha P Gunawardena; Katelyn E Zulauf; Seidu Malik; Jennifer E Griffin; Christopher M Sassetti; Xian Chen; Miriam Braunstein
Journal:  Mol Cell Proteomics       Date:  2015-03-26       Impact factor: 5.911

4.  Protein export by the mycobacterial SecA2 system is determined by the preprotein mature domain.

Authors:  Meghan E Feltcher; Henry S Gibbons; Lauren S Ligon; Miriam Braunstein
Journal:  J Bacteriol       Date:  2012-11-30       Impact factor: 3.490

Review 5.  Biogenesis and functions of bacterial S-layers.

Authors:  Robert P Fagan; Neil F Fairweather
Journal:  Nat Rev Microbiol       Date:  2014-02-10       Impact factor: 60.633

6.  A conserved domain is crucial for acceptor substrate binding in a family of glucosyltransferases.

Authors:  Fan Zhu; Hua Zhang; Hui Wu
Journal:  J Bacteriol       Date:  2014-11-17       Impact factor: 3.490

Review 7.  Breaking the bacterial protein targeting and translocation model: oral organisms as a case in point.

Authors:  N E Lewis; L J Brady
Journal:  Mol Oral Microbiol       Date:  2014-12-26       Impact factor: 3.563

Review 8.  The Sec-dependent pathway.

Authors:  Jon Beckwith
Journal:  Res Microbiol       Date:  2013-03-26       Impact factor: 3.992

9.  Bacteriocin protein BacL1 of Enterococcus faecalis is a peptidoglycan D-isoglutamyl-L-lysine endopeptidase.

Authors:  Jun Kurushima; Ikue Hayashi; Motoyuki Sugai; Haruyoshi Tomita
Journal:  J Biol Chem       Date:  2013-11-14       Impact factor: 5.157

10.  Virulence Gene-Associated Mutant Bacterial Colonies Generate Differentiating Two-Dimensional Laser Scatter Fingerprints.

Authors:  Atul K Singh; Lena Leprun; Rishi Drolia; Xingjian Bai; Huisung Kim; Amornrat Aroonnual; Euiwon Bae; Krishna K Mishra; Arun K Bhunia
Journal:  Appl Environ Microbiol       Date:  2016-05-16       Impact factor: 4.792
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