Reduced metaboreflex control of blood pressure during exercise in individuals with intellectual disability: a possible contributor to exercise intolerance.

The aim was to investigate the hemodynamic responses to isometric handgrip exercise (HG) and examine the role of the muscle metaboreflex in the exercise pressor response in individuals with intellectual disability (IID) and non-disabled control subjects. Eleven males with mild-moderate intellectual disabilities and eleven non-disabled males performed a testing protocol involving 3-min periods of baseline, HG exercise (at 30% MVC), circulatory occlusion, and recovery. The same protocol was repeated without occlusion. At baseline, no differences were detected between groups in beat-to-beat mean arterial pressure (MAP), heart rate (HR), stroke volume, and peripheral resistance. IID were able to sustain an exercise MAP response at comparable levels to the control group exerting similar peripheral resistance; however, IID exhibited a blunted chronotropic response to HG and a diminished exercise vagal withdrawal compared to controls. During occlusion, IID exhibited a lower pressor response than their control peers, associated with a lower increase in peripheral resistance during this task. In conclusion, although intellectual disabilities can be the consequence of many different genes, IID share common deficits in the chronotropic response to exercise and a blunted metaboreflex-induced pressor response.