| Literature DB >> 23000294 |
Kelly C G Moura1, Paula F Carneiro, Maria do Carmo F R Pinto, José A da Silva, Valéria R S Malta, Carlos A de Simone, Gleiston G Dias, Guilherme A M Jardim, Jéssica Cantos, Tatiane S Coelho, Pedro E Almeida da Silva, Eufrânio N da Silva.
Abstract
Twenty-three naphthoimidazoles and six naphthoxazoles were synthesised and evaluated against susceptible and rifampicin- and isoniazid-resistant strains of Mycobacterium tuberculosis. Among all the compounds evaluated, fourteen presented MIC values in the range of 0.78 to 6.25 μg/mL against susceptible and resistant strains of M. tuberculosis. Five structures were solved by X-ray crystallographic analysis. These substances are promising antimycobacterial prototypes.Entities:
Mesh：
Substances：
Year: 2012 PMID： 23000294 DOI： 10.1016/j.bmc.2012.08.041
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641