BACKGROUND: In most cases, the natural healing of intrabony defects only leads to restoration of tissue continuity without differentiation and function. However, repair is not regarded to be an optimal treatment method, as confirmed in many clinical cases. Thus it is important to choose a surgical procedure which makes it possible to achieve restitution ad integrum of the bone structure. The choice of the GBR technique is crucial, in terms of the clinical conditions and limitations resulting from the use of a particular material. OBJECTIVE: The objective of this study has been the analysis of effectiveness of selected surgical treatment techniques of intrabony defects in rabbits. MATERIALS AND METHODS: Research was conducted on 36 white rabbits. The operation technique was a criterion of division into 3 groups: BG/BOC (Bio-Oss Collagen(®)+Bio-Gide Perio(®)), BOC/PRP (Bio-Oss Collagen(®)+PRP), C (control group). Qualitative and quantitative histopathological evaluation was carried out after 1, 3, 6 and 12 months. RESULTS: The highest value of the bone surface area 31.9% (SD 1.8) was achieved in BOC/BG group three months after the implantation, while the lowest was revealed in C - group - 12.5% (SD 1.32) one month following the procedure. CONCLUSIONS: Upon quantitative histological assessment, the bone tissue presented the most intensive osteogenesis within one month from the application of BOC/PRP, whereas this was observed after the application of BOC/BG in later stages. The application of two regenerative methods influenced the rate, quality and overall treatment of intraosseus defects.
BACKGROUND: In most cases, the natural healing of intrabony defects only leads to restoration of tissue continuity without differentiation and function. However, repair is not regarded to be an optimal treatment method, as confirmed in many clinical cases. Thus it is important to choose a surgical procedure which makes it possible to achieve restitution ad integrum of the bone structure. The choice of the GBR technique is crucial, in terms of the clinical conditions and limitations resulting from the use of a particular material. OBJECTIVE: The objective of this study has been the analysis of effectiveness of selected surgical treatment techniques of intrabony defects in rabbits. MATERIALS AND METHODS: Research was conducted on 36 white rabbits. The operation technique was a criterion of division into 3 groups: BG/BOC (Bio-Oss Collagen(®)+Bio-Gide Perio(®)), BOC/PRP (Bio-Oss Collagen(®)+PRP), C (control group). Qualitative and quantitative histopathological evaluation was carried out after 1, 3, 6 and 12 months. RESULTS: The highest value of the bone surface area 31.9% (SD 1.8) was achieved in BOC/BG group three months after the implantation, while the lowest was revealed in C - group - 12.5% (SD 1.32) one month following the procedure. CONCLUSIONS: Upon quantitative histological assessment, the bone tissue presented the most intensive osteogenesis within one month from the application of BOC/PRP, whereas this was observed after the application of BOC/BG in later stages. The application of two regenerative methods influenced the rate, quality and overall treatment of intraosseus defects.
Authors: Leila S Coimbra; Joao Paulo Steffens; Carlos Rossa; Dana T Graves; Luis C Spolidorio Journal: J Clin Periodontol Date: 2014-01-16 Impact factor: 8.728
Authors: Rafael Comesaña; Fernando Lusquiños; Jesús Del Val; Félix Quintero; Antonio Riveiro; Mohamed Boutinguiza; Julian R Jones; Robert G Hill; Juan Pou Journal: Sci Rep Date: 2015-06-02 Impact factor: 4.379