Shay Porat1, Hagai Amsalem, Prakesh S Shah, Kellie E Murphy. 1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mt Sinai Hospital, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Abstract
OBJECTIVE: The purpose of this study was to review systematically the efficacy of transabdominal amnioinfusion (TA) in early preterm premature rupture of membranes (PPROM). STUDY DESIGN: We conducted a literature search of EMBASE, MEDLINE, and ClinicalTrials.gov databases and identified studies in which TA was used in cases of proven PPROM and oligohydramnios. Risk of bias was assessed for observational studies and randomized controlled trials. Primary outcomes were latency period and perinatal mortality rates. RESULTS: Four observational studies (n = 147) and 3 randomized controlled trials (n = 165) were eligible. Pooled latency period was 14.4 (range, 8.2-20.6) and 11.41 (range -3.4 to 26.2) days longer in the TA group in the observational and the randomized controlled trials, respectively. Perinatal mortality rates were reduced among the treatment groups in both the observational studies (odds ratio, 0.12; 95% confidence interval, 0.02-0.61) and the randomized controlled trials (odds ratio, 0.33; 95% confidence interval, 0.10-1.12). CONCLUSION: Serial TA for early PPROM may improve early PPROM-associated morbidity and mortality rates. Additional adequately powered randomized control trials are needed.
OBJECTIVE: The purpose of this study was to review systematically the efficacy of transabdominal amnioinfusion (TA) in early preterm premature rupture of membranes (PPROM). STUDY DESIGN: We conducted a literature search of EMBASE, MEDLINE, and ClinicalTrials.gov databases and identified studies in which TA was used in cases of proven PPROM and oligohydramnios. Risk of bias was assessed for observational studies and randomized controlled trials. Primary outcomes were latency period and perinatal mortality rates. RESULTS: Four observational studies (n = 147) and 3 randomized controlled trials (n = 165) were eligible. Pooled latency period was 14.4 (range, 8.2-20.6) and 11.41 (range -3.4 to 26.2) days longer in the TA group in the observational and the randomized controlled trials, respectively. Perinatal mortality rates were reduced among the treatment groups in both the observational studies (odds ratio, 0.12; 95% confidence interval, 0.02-0.61) and the randomized controlled trials (odds ratio, 0.33; 95% confidence interval, 0.10-1.12). CONCLUSION: Serial TA for early PPROM may improve early PPROM-associated morbidity and mortality rates. Additional adequately powered randomized control trials are needed.
Authors: Abdulkadir Turgut; Selahattin Katar; Muhammet Erdal Sak; Fethiye Gülden Turgut; Alparslan Sahin; Serdar Başaranoğlu; Ahmet Yalınkaya Journal: J Turk Ger Gynecol Assoc Date: 2013-12-01
Authors: A A de Ruigh; N E Simons; J van 't Hooft; A S van Teeffelen; R G Duijnhoven; A G van Wassenaer-Leemhuis; C Aarnoudse-Moens; C van de Beek; D Oepkes; M C Haak; M Woiski; M M Porath; J B Derks; Lem van Kempen; T J Roseboom; B W Mol; E Pajkrt Journal: BJOG Date: 2020-03-04 Impact factor: 7.331
Authors: Augustinus S P van Teeffelen; David P van der Ham; Christine Willekes; Salwan Al Nasiry; Jan G Nijhuis; Sander van Kuijk; Ewoud Schuyt; Twan L M Mulder; Maureen T M Franssen; Dick Oepkes; Fenna A R Jansen; Mallory D Woiski; Mireille N Bekker; Caroline J Bax; Martina M Porath; Monique W M de Laat; Ben W Mol; Eva Pajkrt Journal: BMC Pregnancy Childbirth Date: 2014-04-04 Impact factor: 3.007