Literature DB >> 22998568

Flavonoids acting on DNA topoisomerases: recent advances and future perspectives in cancer therapy.

P Russo1, A Del Bufalo, A Cesario.   

Abstract

Flavonoids, secondary metabolites ubiquitously produced in the plant kingdom, are low molecular weight polyphenolic molecules. They are characterized by variable chemical structures and show a vast array of biological activities (i.e... antiviral, antiinflammatory, antitumor, antimicrobial, estrogenic, antiestrogenic, antioxidant, mutagenic and antimutagenic) targeting different pathways. Some of these compounds such as Genistein, Daidzein or its synthetic derivative Phenoxodiol as well as Luteolin and Quercetin are able to inhibit DNA topoisomerases. This review discusses that Flavonoids targeting DNA topoisomerases may lead to novel drug development with anticancer potential.

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Year:  2012        PMID： 22998568     DOI： 10.2174/092986712803833272

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  15 in total

Review 1.  Trans-acting small interfering RNA4: key to nutraceutical synthesis in grape development?

Authors:  Christopher D Rock
Journal:  Trends Plant Sci       Date:  2013-08-28       Impact factor: 18.313

2.  Design, Synthesis, and Evaluation of Genistein Analogues as Anti-Cancer Agents.

Authors:  Pahoua Xiong; Rubing Wang; Xiaojie Zhang; Eduardo DeLa Torre; Francisco Leon; Qiang Zhang; Shilong Zheng; Guangdi Wang; Qiao-Hong Chen
Journal:  Anticancer Agents Med Chem       Date:  2015       Impact factor: 2.505

3.  Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-α-stimulated murine lung epithelial cells via depressing PARP-1 activity.

Authors:  Hai-yan Li; Lang Pan; Yue-shuang Ke; Enkhzaya Batnasan; Xiang-qun Jin; Zhong-ying Liu; Xue-qing Ba
Journal:  Acta Pharmacol Sin       Date:  2014-03-17       Impact factor: 6.150

4.  Anticancer potential of selected Fallopia Adans species.

Authors:  Octavian Tudorel Olaru; Luanne Venables; Maryna VAN DE Venter; George Mihai Nitulescu; Denisa Margina; Demetrios A Spandidos; Aristidis M Tsatsakis
Journal:  Oncol Lett       Date:  2015-07-02       Impact factor: 2.967

5.  Antitumor activity of total flavonoids from Tetrastigma hemsleyanum Diels et Gilg is associated with the inhibition of regulatory T cells in mice.

Authors:  Zhengquan Feng; Wanrong Hao; Xiaoyang Lin; Daping Fan; Juhua Zhou
Journal:  Onco Targets Ther       Date:  2014-06-09       Impact factor: 4.147

6.  Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.

Authors:  Li Feng; Marcus M Maddox; Md Zahidul Alam; Lissa S Tsutsumi; Gagandeep Narula; David F Bruhn; Xiaoqian Wu; Shayna Sandhaus; Robin B Lee; Charles J Simmons; Yuk-Ching Tse-Dinh; Julian G Hurdle; Richard E Lee; Dianqing Sun
Journal:  J Med Chem       Date:  2014-10-07       Impact factor: 7.446

Review 7.  Protective Effects of Chrysin Against Drugs and Toxic Agents.

Authors:  Saeed Samarghandian; Tahereh Farkhondeh; Mohsen Azimi-Nezhad
Journal:  Dose Response       Date:  2017-06-23       Impact factor: 2.658

8.  Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.

Authors:  Mounira Krifa; Mahmoud Alhosin; Christian D Muller; Jean-Pierre Gies; Leila Chekir-Ghedira; Kamel Ghedira; Yves Mély; Christian Bronner; Marc Mousli
Journal:  J Exp Clin Cancer Res       Date:  2013-05-20

9.  Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells.

Authors:  Zhuhong Zhang; Si Chen; Hu Mei; Jiekun Xuan; Xiaoqing Guo; Letha Couch; Vasily N Dobrovolsky; Lei Guo; Nan Mei
Journal:  Sci Rep       Date:  2015-09-30       Impact factor: 4.379

10.  Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630.

Authors:  Minami A Sakurai; Yuki Ozaki; Daisuke Okuzaki; Yoko Naito; Towa Sasakura; Ayumi Okamoto; Hiroe Tabara; Takao Inoue; Man Hagiyama; Akihiko Ito; Norikazu Yabuta; Hiroshi Nojima
Journal:  PLoS One       Date:  2014-06-27       Impact factor: 3.240
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