| Literature DB >> 22997417 |
Shin-Hee Kim1, Subhashree Nayak, Anandan Paldurai, Baibaswata Nayak, Arthur Samuel, Gilbert L Aplogan, Kodzo A Awoume, Richard J Webby, Mariette F Ducatez, Peter L Collins, Siba K Samal.
Abstract
The complete genome sequence of an African Newcastle disease virus (NDV) strain isolated from a chicken in Togo in 2009 was determined. The genome is 15,198 nucleotides (nt) in length and is classified in genotype VII in the class II cluster. Compared to common vaccine strains, the African strain contains a previously described 6-nt insert in the downstream untranslated region of the N gene and a novel 6-nt insert in the HN-L intergenic region. Genome length differences are a marker of the natural history of NDV. This is the first description of a class II NDV strain with a genome of 15,198 nt and a 6-nt insert in the HN-L intergenic region. Sequence divergence relative to vaccine strains was substantial, likely contributes to outbreaks, and illustrates the continued evolution of new NDV strains in West Africa.Entities:
Mesh：
Year: 2012 PMID： 22997417 PMCID： PMC3457136 DOI： 10.1128/JVI.01922-12
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103