OBJECTIVES: This study sought to assess the contemporary outcomes of patients with prior coronary artery bypass graft (CABG) who present with moderate and high-risk acute coronary syndromes (ACS) and are treated with an early invasive strategy and contemporary antithrombin regimens. BACKGROUND: The prognosis of patients with ACS and prior CABG in relation to triage strategy and contemporary antithrombotic regimens is unknown. METHODS: In the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial, 2,475 of 13,764 patients (18.0%) with ACS managed with an early invasive strategy had previously undergone CABG. Their outcomes were examined according to treatment and randomized antithrombin regimen. RESULTS: Prior CABG was associated with older age, more frequent comorbidities, higher Thrombolysis In Myocardial Infarction risk score, and lower left ventricular ejection fraction. Patients with versus without prior CABG were less likely to undergo (repeat) CABG and were more likely to be managed medically. At 1 year, patients with versus without prior CABG had higher rates of major adverse cardiac events (MACE) (22.5% vs. 15.2%, p < 0.0001) due to greater mortality (5.4% vs. 3.9%, p < 0.0001), myocardial infarction (10.0% vs. 6.8%, p < 0.0001), and unplanned revascularization (13.1% vs. 8.2%, p < 0.0001). History of CABG was an independent predictor of MACE. The 1-year MACE rates were not significantly different after randomization to bivalirudin versus heparin plus a glycoprotein IIb/IIIa inhibitor (odds ratio: 1.24, 95% confidence interval: 0.90 to 1.70). CONCLUSIONS: Despite the progress in the treatment of coronary artery disease, patients with prior CABG and ACS have a poor prognosis, substantially worse than for those without prior CABG. Whereas bivalirudin monotherapy was an acceptable treatment for these patients, it did not improve their prognoses.
RCT Entities:
OBJECTIVES: This study sought to assess the contemporary outcomes of patients with prior coronary artery bypass graft (CABG) who present with moderate and high-risk acute coronary syndromes (ACS) and are treated with an early invasive strategy and contemporary antithrombin regimens. BACKGROUND: The prognosis of patients with ACS and prior CABG in relation to triage strategy and contemporary antithrombotic regimens is unknown. METHODS: In the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial, 2,475 of 13,764 patients (18.0%) with ACS managed with an early invasive strategy had previously undergone CABG. Their outcomes were examined according to treatment and randomized antithrombin regimen. RESULTS: Prior CABG was associated with older age, more frequent comorbidities, higher Thrombolysis In Myocardial Infarction risk score, and lower left ventricular ejection fraction. Patients with versus without prior CABG were less likely to undergo (repeat) CABG and were more likely to be managed medically. At 1 year, patients with versus without prior CABG had higher rates of major adverse cardiac events (MACE) (22.5% vs. 15.2%, p < 0.0001) due to greater mortality (5.4% vs. 3.9%, p < 0.0001), myocardial infarction (10.0% vs. 6.8%, p < 0.0001), and unplanned revascularization (13.1% vs. 8.2%, p < 0.0001). History of CABG was an independent predictor of MACE. The 1-year MACE rates were not significantly different after randomization to bivalirudin versus heparin plus a glycoprotein IIb/IIIa inhibitor (odds ratio: 1.24, 95% confidence interval: 0.90 to 1.70). CONCLUSIONS: Despite the progress in the treatment of coronary artery disease, patients with prior CABG and ACS have a poor prognosis, substantially worse than for those without prior CABG. Whereas bivalirudin monotherapy was an acceptable treatment for these patients, it did not improve their prognoses.
Authors: Muhammad Asrar Ul Haq; Nima Rudd; Mueed Mian; Anastasia Castles; Tamara Mogilevski; Vivek Mutha; William J Van Gaal Journal: Open Heart Date: 2014-06-13
Authors: Matthew M Y Lee; Mark C Petrie; Paul Rocchiccioli; Joanne Simpson; Colette E Jackson; David S Corcoran; Kenneth Mangion; Ammani Brown; Pio Cialdella; Novalia P Sidik; Margaret B McEntegart; Aadil Shaukat; Alan P Rae; Stuart H M Hood; Eileen E Peat; Iain N Findlay; Clare L Murphy; Alistair J Cormack; Nikolay B Bukov; Kanarath P Balachandran; Keith G Oldroyd; Ian Ford; Olivia Wu; Alex McConnachie; Sarah J E Barry; Colin Berry Journal: Circ Cardiovasc Interv Date: 2019-07-31 Impact factor: 6.546
Authors: Matthew M Y Lee; Mark C Petrie; Paul Rocchiccioli; Joanne Simpson; Colette E Jackson; David S Corcoran; Kenneth Mangion; Ammani Brown; Pio Cialdella; Novalia P Sidik; Margaret B McEntegart; Aadil Shaukat; Alan P Rae; Stuart H M Hood; Eileen E Peat; Iain N Findlay; Clare L Murphy; Alistair J Cormack; Nikolay B Bukov; Kanarath P Balachandran; Ian Ford; Olivia Wu; Alex McConnachie; Sarah J E Barry; Colin Berry Journal: Open Heart Date: 2021-02
Authors: Andreas Seraphim; Kristopher D Knott; Joao B Augusto; Katia Menacho; Sara Tyebally; Benjamin Dowsing; Sanjeev Bhattacharyya; Leon J Menezes; Daniel A Jones; Rakesh Uppal; James C Moon; Charlotte Manisty Journal: Front Cardiovasc Med Date: 2021-12-23
Authors: Matthew M Y Lee; Mark C Petrie; Paul Rocchiccioli; Joanne Simpson; Colette Jackson; Ammani Brown; David Corcoran; Kenneth Mangion; Margaret McEntegart; Aadil Shaukat; Alan Rae; Stuart Hood; Eileen Peat; Iain Findlay; Clare Murphy; Alistair Cormack; Nikolay Bukov; Kanarath Balachandran; Richard Papworth; Ian Ford; Andrew Briggs; Colin Berry Journal: Open Heart Date: 2016-04-20
Authors: Liefke C van der Heijden; Marlies M Kok; Paolo Zocca; Hanim Sen; Marije M Löwik; Silvia Mariani; Frits H A F de Man; Marc Hartmann; Martin G Stoel; K Gert van Houwelingen; J Hans W Louwerenburg; Gerard C M Linssen; Carine J M Doggen; Jan G Grandjean; Clemens von Birgelen Journal: J Am Heart Assoc Date: 2018-01-30 Impact factor: 5.501