BACKGROUND: Antioxidant intake may reduce the risk of allergic disease by protecting against oxidative tissue damage. Major sources of antioxidants in the Western world are fruits, vegetables (vitamin C, β-carotene, α-tocopherol), meat and milk (selenium, magnesium, zinc). Children may exclude or eat less of some fruits and vegetables due to cross-reactivity between pollen and these foods, complicating assessment of causal relationships. OBJECTIVE: To investigate the association between dietary antioxidant intake and allergic disease, taking potential reverse causation into account. METHODS: Data on 2442 8-year-old children from the Swedish birth cohort study BAMSE were analysed. Children with completed parental questionnaires on exposures and health, including a food-frequency questionnaire and who provided a blood sample were included. Associations between antioxidant intake during the past year and current allergic disease were analysed using logistic regression. RESULTS: An inverse association was observed between intake of β-carotene and rhinitis (OR(adj), highest vs. lowest quartile, 0.67, 95% CI 0.49-0.93). Magnesium intake was inversely related to asthma (OR(adj), 0.65, 95% CI 0.42-1.00) and atopic sensitisation (OR(adj), 0.78, 95% CI 0.61-1.00). Following exclusion of children who avoided certain fruits, vegetables or milk due to allergic symptoms (n = 285), the inverse association remained between magnesium intake and asthma (OR(adj), 0.58, 95% CI 0.35-0.98), whereas all other associations became non-significant. CONCLUSION AND CLINICAL RELEVANCE: Diet modifications due to allergy may affect the antioxidant intake and needs to be considered when investigating the relationship between diet and allergic disease. Magnesium intake seems to have a protective effect on childhood asthma.
BACKGROUND: Antioxidant intake may reduce the risk of allergic disease by protecting against oxidative tissue damage. Major sources of antioxidants in the Western world are fruits, vegetables (vitamin C, β-carotene, α-tocopherol), meat and milk (selenium, magnesium, zinc). Children may exclude or eat less of some fruits and vegetables due to cross-reactivity between pollen and these foods, complicating assessment of causal relationships. OBJECTIVE: To investigate the association between dietary antioxidant intake and allergic disease, taking potential reverse causation into account. METHODS: Data on 2442 8-year-old children from the Swedish birth cohort study BAMSE were analysed. Children with completed parental questionnaires on exposures and health, including a food-frequency questionnaire and who provided a blood sample were included. Associations between antioxidant intake during the past year and current allergic disease were analysed using logistic regression. RESULTS: An inverse association was observed between intake of β-carotene and rhinitis (OR(adj), highest vs. lowest quartile, 0.67, 95% CI 0.49-0.93). Magnesium intake was inversely related to asthma (OR(adj), 0.65, 95% CI 0.42-1.00) and atopic sensitisation (OR(adj), 0.78, 95% CI 0.61-1.00). Following exclusion of children who avoided certain fruits, vegetables or milk due to allergic symptoms (n = 285), the inverse association remained between magnesium intake and asthma (OR(adj), 0.58, 95% CI 0.35-0.98), whereas all other associations became non-significant. CONCLUSION AND CLINICAL RELEVANCE: Diet modifications due to allergy may affect the antioxidant intake and needs to be considered when investigating the relationship between diet and allergic disease. Magnesium intake seems to have a protective effect on childhood asthma.
Authors: George Antonogeorgos; Demosthenes B Panagiotakos; Kostas N Priftis; Evangelia Liakou; Alexandra Koutsokera; Pavlos Drakontaeidis; Marina Thanasia; Maria Mandrapylia; Dafni Moriki; Philippa Ellwood; Luis García-Marcos; Konstantinos Douros Journal: Children (Basel) Date: 2022-05-09
Authors: A Gref; S Rautiainen; O Gruzieva; N Håkansson; I Kull; G Pershagen; M Wickman; A Wolk; E Melén; A Bergström Journal: Clin Exp Allergy Date: 2017-03-14 Impact factor: 5.018
Authors: Philip W Rouadi; Samar A Idriss; Robert M Naclerio; David B Peden; Ignacio J Ansotegui; Giorgio Walter Canonica; Sandra Nora Gonzalez-Diaz; Nelson A Rosario Filho; Juan Carlos Ivancevich; Peter W Hellings; Margarita Murrieta-Aguttes; Fares H Zaitoun; Carla Irani; Marilyn R Karam; Jean Bousquet Journal: World Allergy Organ J Date: 2020-10-05 Impact factor: 4.084