| Literature DB >> 22993407 |
Kaarina Ranta1, Kaisa Nieminen, Filip S Ekholm, Moniká Poláková, Mattias U Roslund, Tiina Saloranta, Reko Leino, Johannes Savolainen.
Abstract
Immunostimulatory properties of synthetic structures mimicking the β-(1→2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(α-D-mannopyranosyloxy)butane induced TNF and some molecules induced low levels of gamma interferon (IFN-γ) in human peripheral blood mononuclear cells (PBMC).Entities:
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Year: 2012 PMID: 22993407 PMCID: PMC3491550 DOI: 10.1128/CVI.00298-12
Source DB: PubMed Journal: Clin Vaccine Immunol ISSN: 1556-679X