Systemic inflammatory response predicts perioperative central venous catheter-related bloodstream infection in patients Undergoing colorectal cancer surgery with administration of parenteral nutrition.

Our aim was to examine whether systemic inflammatory response (SIR) is associated with perioperative central venous catheter-related bloodstream infection (CVC-RBSI) in patients undergoing surgery for colorectal cancer (CRC) with administration of parenteral nutrition (PN). Between May 2002 and August 2009, 310 patients undergoing CRC surgery were enrolled. A CVC was inserted in all patients for administration of PN. Among these patients, 117 developed fever, and blood cultures for diagnosis of CVC-RBSI were obtained from them. A final total of 22 patients were diagnosed as having CVC-RBSI. Univariate analysis was performed to evaluate the risk factors for CVC-RBSI using the clinical characteristics of the patients. The results of univariate analyses revealed that only the Glasgow Prognostic Score was an independent risk factor for CVC-RBSI (odds ratio 3.733; 95% confidence interval 1.416-9.844; p=0.008). The Glasgow Prognostic Score is associated with CVC-RBSI in patients undergoing CRC surgery with administration of PN.