BACKGROUND: Concurrent chemoradiotherapy (CCRT) improves survival and organ preservation in patients with head and neck squamous cell carcinoma (HNSCC), compared with radiotherapy. However, such regimens are not always feasible because of substantial toxicities. Therefore, we evaluated the feasibility of S-1, administered on alternate days, and concurrent radiotherapy among elderly patients with HNSCC. PATIENTS AND METHODS: Nineteen eligible patients were treated with CCRT. S-1 was administered at a dose of 80 mg/day on alternate days with the intention to reduce the toxicity. RESULTS: With a median follow-up period of 19.2 months, the two-year overall survival rates were 62.5% for patients with stage III disease and 50.0% for those with stage IV. The Complete Response (CR) rates were 100% for stage II and 66.7% for stage III/IV disease. Grade 3 mucositis occurred in three patients. Grade 3 or 4 hematological toxicities were not observed. CONCLUSION: CCRT with S-1 administered on alternate days was effective and well-tolerated among elderly patients with HNSCC.
BACKGROUND: Concurrent chemoradiotherapy (CCRT) improves survival and organ preservation in patients with head and neck squamous cell carcinoma (HNSCC), compared with radiotherapy. However, such regimens are not always feasible because of substantial toxicities. Therefore, we evaluated the feasibility of S-1, administered on alternate days, and concurrent radiotherapy among elderly patients with HNSCC. PATIENTS AND METHODS: Nineteen eligible patients were treated with CCRT. S-1 was administered at a dose of 80 mg/day on alternate days with the intention to reduce the toxicity. RESULTS: With a median follow-up period of 19.2 months, the two-year overall survival rates were 62.5% for patients with stage III disease and 50.0% for those with stage IV. The Complete Response (CR) rates were 100% for stage II and 66.7% for stage III/IV disease. Grade 3 mucositis occurred in three patients. Grade 3 or 4 hematological toxicities were not observed. CONCLUSION: CCRT with S-1 administered on alternate days was effective and well-tolerated among elderly patients with HNSCC.
Authors: Ronald J Maggiore; Emily K Curran; Mary Ellyn Witt; Daniel J Haraf; Everett E Vokes; Ezra E W Cohen Journal: J Geriatr Oncol Date: 2013-06-10 Impact factor: 3.599
Authors: Romain Rivoirard; Coralie Moncharmont; Avi Assouline; Pierre Auberdiac; Benoite Mery; Alexander Tuan Falk; Pierre Annède; Jane-Chloé Trone; Jean-Baptiste Guy; Nicolas Vial; Pierre Fournel; Yacine Merrouche; Cyrus Chargari; Nicolas Magné Journal: Eur Arch Otorhinolaryngol Date: 2014-04-02 Impact factor: 2.503