BACKGROUND: The primary risk factor for chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) is cigarette smoking but shared susceptibility factors, such as variations in the matrix metalloproteinase-1 (MMP1) gene, may also underlie both diseases. MATERIALS AND METHODS: Cases with prevalent COPD (n=167), incident NSCLC (n=242), or prevalent COPD plus incident NSCLC (n=128) were compared to disease-free controls (n=338) to assess six MMP1 polymorphisms. The association between these polymorphisms and survival in NSCLC was also evaluated. RESULTS: Rs11292517 among African-Americans [odds ratio (OR)=5.48, 95% confidence interval (CI)=1.17-25.72] and rs2071230 among Caucasians (OR=2.51, 95% CI=1.09-5.77) appeared to be associated with NSCLC risk in the presence of COPD. Rs470558 appeared to be associated with survival in NSCLC among African-Americans (hazard ratio=3.94; 95%CI=1.14-13.63). No associations remained after adjusting for multiple comparisons. CONCLUSION: Polymorphisms in MMP1 were not consistently associated with prevalent COPD or incident NSCLC nor with survival in NSCLC.
BACKGROUND: The primary risk factor for chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) is cigarette smoking but shared susceptibility factors, such as variations in the matrix metalloproteinase-1 (MMP1) gene, may also underlie both diseases. MATERIALS AND METHODS: Cases with prevalent COPD (n=167), incident NSCLC (n=242), or prevalent COPD plus incident NSCLC (n=128) were compared to disease-free controls (n=338) to assess six MMP1 polymorphisms. The association between these polymorphisms and survival in NSCLC was also evaluated. RESULTS:Rs11292517 among African-Americans [odds ratio (OR)=5.48, 95% confidence interval (CI)=1.17-25.72] and rs2071230 among Caucasians (OR=2.51, 95% CI=1.09-5.77) appeared to be associated with NSCLC risk in the presence of COPD. Rs470558 appeared to be associated with survival in NSCLC among African-Americans (hazard ratio=3.94; 95%CI=1.14-13.63). No associations remained after adjusting for multiple comparisons. CONCLUSION: Polymorphisms in MMP1 were not consistently associated with prevalent COPD or incident NSCLC nor with survival in NSCLC.
Authors: Li Su; Wei Zhou; Sohee Park; John C Wain; Thomas J Lynch; Geoffrey Liu; David C Christiani Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-03 Impact factor: 4.254
Authors: Rebecca Suk Heist; Ariela L Marshall; Geoffrey Liu; Wei Zhou; Li Su; Donna Neuberg; Thomas J Lynch; John Wain; David C Christiani Journal: Clin Cancer Res Date: 2006-09-15 Impact factor: 12.531
Authors: Li Su; Wei Zhou; Kofi Asomaning; Xihong Lin; John C Wain; Thomas J Lynch; Geoffrey Liu; David C Christiani Journal: Carcinogenesis Date: 2005-11-25 Impact factor: 4.944
Authors: Y Kanamori; M Matsushima; T Minaguchi; K Kobayashi; S Sagae; R Kudo; N Terakawa; Y Nakamura Journal: Cancer Res Date: 1999-09-01 Impact factor: 12.701
Authors: J L Rutter; T I Mitchell; G Butticè; J Meyers; J F Gusella; L J Ozelius; C E Brinckerhoff Journal: Cancer Res Date: 1998-12-01 Impact factor: 12.701