Literature DB >> 22993146

Kaposi's sarcoma-associated herpesvirus ORF57 is not a bona fide export factor.

Guy R Pilkington1, Vladimir Majerciak, Jenifer Bear, Hiroaki Uranishi, Zhi-Ming Zheng, Barbara K Felber.   

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV [human herpesvirus 8; HHV-8]) open reading frame 57 (ORF57) is a viral early protein participating in posttranscriptional regulatory events, such as splicing, RNA stabilization, and protein expression. Recent data suggest that ORF57 recruits the transcription and export (TREX) complex to viral RNA and exports these transcripts to the cytoplasm. In this study, we show that although ORF57 promotes expression of a selection of KSHV viral intronless RNAs, it is not a bona fide export factor.

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Year:  2012        PMID： 22993146      PMCID： PMC3497679          DOI： 10.1128/JVI.00606-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

Review 1.  TREX, SR proteins and export of mRNA.

Authors:  Robin Reed; Hong Cheng
Journal:  Curr Opin Cell Biol       Date:  2005-06       Impact factor: 8.382

2.  Exon junction complexes mediate the enhancing effect of splicing on mRNA expression.

Authors:  Heather L Wiegand; Shihua Lu; Bryan R Cullen
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-12       Impact factor: 11.205

3.  Recruitment of the human TREX complex to mRNA during splicing.

Authors:  Seiji Masuda; Rita Das; Hong Cheng; Ed Hurt; Nijsje Dorman; Robin Reed
Journal:  Genes Dev       Date:  2005-07-01       Impact factor: 11.361

4.  rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

Authors:  B K Felber; M Hadzopoulou-Cladaras; C Cladaras; T Copeland; G N Pavlakis
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

5.  Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8).

Authors:  J J Russo; R A Bohenzky; M C Chien; J Chen; M Yan; D Maddalena; J P Parry; D Peruzzi; I S Edelman; Y Chang; P S Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

6.  ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathway.

Authors:  I-Hsiung Brandon Chen; Kathryn S Sciabica; Rozanne M Sandri-Goldin
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

7.  Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activities.

Authors:  J R Kirshner; D M Lukac; J Chang; D Ganem
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

8.  The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor.

Authors:  Poonam Malik; David J Blackbourn; J Barklie Clements
Journal:  J Biol Chem       Date:  2004-05-20       Impact factor: 5.157

9.  Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap.

Authors:  F Nappi; R Schneider; A Zolotukhin; S Smulevitch; D Michalowski; J Bear; B K Felber; G N Pavlakis
Journal:  J Virol       Date:  2001-05       Impact factor: 6.549

10.  Stability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1.

Authors:  Maria J Massimelli; Jeong-Gu Kang; Vladimir Majerciak; Shu-Yun Le; David J Liewehr; Seth M Steinberg; Zhi-Ming Zheng
Journal:  Int J Biol Sci       Date:  2011-10-16       Impact factor: 6.580
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  11 in total

1.  Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.

Authors:  Vladimir Majerciak; Natalia Pripuzova; Calvin Chan; Nicholas Temkin; Suzanne I Specht; Zhi-Ming Zheng
Journal:  J Virol       Date:  2015-01-07       Impact factor: 5.103

2.  CRISPR/Cas9-Mediated Knockout and In Situ Inversion of the ORF57 Gene from All Copies of the Kaposi's Sarcoma-Associated Herpesvirus Genome in BCBL-1 Cells.

Authors:  Andrew BeltCappellino; Vladimir Majerciak; Alexei Lobanov; Justin Lack; Maggie Cam; Zhi-Ming Zheng
Journal:  J Virol       Date:  2019-10-15       Impact factor: 5.103

3.  Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis.

Authors:  Meilan He; Fan Cheng; Suzane Ramos da Silva; Brandon Tan; Océane Sorel; Marion Gruffaz; Tingting Li; Shou-Jiang Gao
Journal:  Cancer Treat Res       Date:  2019

4.  ORF57 overcomes the detrimental sequence bias of Kaposi's sarcoma-associated herpesvirus lytic genes.

Authors:  Carolin Vogt; Christian Hackmann; Alona Rabner; Lars Koste; Susann Santag; Semra Kati; Yael Mandel-Gutfreund; Thomas F Schulz; Jens Bohne
Journal:  J Virol       Date:  2015-02-18       Impact factor: 5.103

5.  Importance of codon usage for the temporal regulation of viral gene expression.

Authors:  Young C Shin; Georg F Bischof; William A Lauer; Ronald C Desrosiers
Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-26       Impact factor: 11.205

6.  Transcriptional and post-transcriptional regulation of viral gene expression in the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus.

Authors:  Matthew Butnaru; Marta M Gaglia
Journal:  Curr Clin Microbiol Rep       Date:  2018-08-03

7.  HITS-CLIP analysis uncovers a link between the Kaposi's sarcoma-associated herpesvirus ORF57 protein and host pre-mRNA metabolism.

Authors:  Emi Sei; Tao Wang; Olga V Hunter; Yang Xie; Nicholas K Conrad
Journal:  PLoS Pathog       Date:  2015-02-24       Impact factor: 6.823

Review 8.  KSHV ORF57, a protein of many faces.

Authors:  Vladimir Majerciak; Zhi-Ming Zheng
Journal:  Viruses       Date:  2015-02-10       Impact factor: 5.048

9.  Attenuation of the suppressive activity of cellular splicing factor SRSF3 by Kaposi sarcoma-associated herpesvirus ORF57 protein is required for RNA splicing.

Authors:  Vladimir Majerciak; Mathew Lu; Xiaofan Li; Zhi-Ming Zheng
Journal:  RNA       Date:  2014-09-18       Impact factor: 4.942

10.  A viral genome landscape of RNA polyadenylation from KSHV latent to lytic infection.

Authors:  Vladimir Majerciak; Ting Ni; Wenjing Yang; Bowen Meng; Jun Zhu; Zhi-Ming Zheng
Journal:  PLoS Pathog       Date:  2013-11-14       Impact factor: 6.823
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