Literature DB >> 22993076

Are ocular complications of a high-dose glucocorticoid treatment appropriately monitored in patients with rheumatic diseases?

Bobby Kwanghoon Han1, Ralph Yachoui, Kayoung Yi.   

Abstract

Glucocorticoid is frequently used in treating various rheumatic conditions. However it is known to cause multiple toxicities including cataract or glaucoma. In this study, we examined whether patients with rheumatic diseases had appropriate ocular monitoring for glucocorticoid toxicities. From rheumatology clinics in South New Jersey of the USA, we retrospectively identified patients with ages between 18 and 60 years old who received a high accumulative dose of glucocorticoid, which was defined as glucocorticoid dose greater than prednisone 7.5mg/day × 6 months = 1,350 mg. We observed rheumatologists recommended eye examinations only in 14/37 (37.8 %) of patients. Family history was present for cataract in 13/37 (35.1 %) patients and for glaucoma in 6/37 (16.2 %) patients. Rheumatologists recommended eye examinations in 4/13 (30.7 %) and 0/6 (0 %) patients in each group. This study suggested that rheumatologists did not appropriately monitor ocular complications of a high dose glucocorticoid, even in patients with a positive family history.

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Year:  2012        PMID: 22993076     DOI: 10.1007/s00296-012-2456-7

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN: 0172-8172            Impact factor:   2.631


  6 in total

1.  Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice.

Authors:  M C van der Goes; J W G Jacobs; M Boers; T Andrews; M A M Blom-Bakkers; F Buttgereit; N Caeyers; M Cutolo; J A P Da Silva; L Guillevin; J R Kirwan; J Rovensky; G Severijns; S Webber; R Westhovens; J W J Bijlsma
Journal:  Ann Rheum Dis       Date:  2010-08-06       Impact factor: 19.103

2.  Population-based assessment of adverse events associated with long-term glucocorticoid use.

Authors:  Jeffrey R Curtis; Andrew O Westfall; Jeroan Allison; Johannes W Bijlsma; Allison Freeman; Varghese George; Stacey H Kovac; Claire M Spettell; Kenneth G Saag
Journal:  Arthritis Rheum       Date:  2006-06-15

3.  Incident comorbidity among patients with rheumatoid arthritis treated or not with low-dose glucocorticoids: a retrospective study.

Authors:  Maurizio Mazzantini; Rosaria Talarico; Marica Doveri; Arianna Consensi; Massimiliano Cazzato; Laura Bazzichi; Stefano Bombardieri
Journal:  J Rheumatol       Date:  2010-09-15       Impact factor: 4.666

4.  Damage in systemic lupus erythematosus and its association with corticosteroids.

Authors:  A Zonana-Nacach; S G Barr; L S Magder; M Petri
Journal:  Arthritis Rheum       Date:  2000-08

5.  The spectrum of ocular involvement in patients with systemic lupus erythematosus without ocular symptoms.

Authors:  M P Soo; S K Chow; C T Tan; N Nadior; S S Yeap; H B Hoh
Journal:  Lupus       Date:  2000       Impact factor: 2.911

6.  Dose-related patterns of glucocorticoid-induced side effects.

Authors:  D Huscher; K Thiele; E Gromnica-Ihle; G Hein; W Demary; R Dreher; A Zink; F Buttgereit
Journal:  Ann Rheum Dis       Date:  2008-08-06       Impact factor: 19.103

  6 in total

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