OBJECTIVE: We tested the hypothesis that fetal pulmonary arterial circulation reacts to changes in fetal oxygenation status at near-term gestation. STUDY DESIGN: A total of 20 rhesus macaques underwent fetal Doppler ultrasonography at near-term gestation. Right pulmonary artery (RPA), umbilical artery (UA), ductus arteriosus (DA), and ductus venosus (DV) blood velocity waveforms were obtained, and pulsatility index (PI) values were calculated. Fetal right and left ventricular cardiac outputs were determined. Ultrasonographic data were collected during 3 maternal oxygenation states: room air (baseline), hyperoxemia, and hypoxemia. RESULTS: Fetal RPA PI values increased (P < .05) during maternal hypoxemia and decreased (P < .05) during maternal hyperoxemia, compared with baseline. Maternal hyperoxemia increased (P < .05) DA PI values from baseline. Fetal cardiac outputs, UA, and DV PI values were not affected. CONCLUSIONS: Our results demonstrate that at near-term gestation, fetal pulmonary arterial circulation is a dynamic vascular bed that reflects acute and short-term changes in fetal oxygenation.
OBJECTIVE: We tested the hypothesis that fetal pulmonary arterial circulation reacts to changes in fetal oxygenation status at near-term gestation. STUDY DESIGN: A total of 20 rhesus macaques underwent fetal Doppler ultrasonography at near-term gestation. Right pulmonary artery (RPA), umbilical artery (UA), ductus arteriosus (DA), and ductus venosus (DV) blood velocity waveforms were obtained, and pulsatility index (PI) values were calculated. Fetal right and left ventricular cardiac outputs were determined. Ultrasonographic data were collected during 3 maternal oxygenation states: room air (baseline), hyperoxemia, and hypoxemia. RESULTS: Fetal RPA PI values increased (P < .05) during maternal hypoxemia and decreased (P < .05) during maternal hyperoxemia, compared with baseline. Maternal hyperoxemia increased (P < .05) DA PI values from baseline. Fetal cardiac outputs, UA, and DV PI values were not affected. CONCLUSIONS: Our results demonstrate that at near-term gestation, fetal pulmonary arterial circulation is a dynamic vascular bed that reflects acute and short-term changes in fetal oxygenation.
Authors: Lindsay S Cahill; Yu-Qing Zhou; Mike Seed; Christopher K Macgowan; John G Sled Journal: J Cereb Blood Flow Metab Date: 2014-04-09 Impact factor: 6.200
Authors: Alec J Hirsch; Victoria H J Roberts; Peta L Grigsby; Nicole Haese; Matthias C Schabel; Xiaojie Wang; Jamie O Lo; Zheng Liu; Christopher D Kroenke; Jessica L Smith; Meredith Kelleher; Rebecca Broeckel; Craig N Kreklywich; Christopher J Parkins; Michael Denton; Patricia Smith; Victor DeFilippis; William Messer; Jay A Nelson; Jon D Hennebold; Marjorie Grafe; Lois Colgin; Anne Lewis; Rebecca Ducore; Tonya Swanson; Alfred W Legasse; Michael K Axthelm; Rhonda MacAllister; Ashlee V Moses; Terry K Morgan; Antonio E Frias; Daniel N Streblow Journal: Nat Commun Date: 2018-01-17 Impact factor: 14.919