Literature DB >> 22990752

The TGF-β pathway as an emerging target for Chagas disease therapy.

T C Araújo-Jorge1, M C Waghabi, S Bailly, J-J Feige.   

Abstract

Transforming growth factor-β (TGF-β) influences the development of myocardiopathy in Chagas disease through regulation of (i) parasite invasion of heart cells, (ii) an intracellular parasite cycle, (iii) inflammation and immune response, (iv) heart fibrosis and remodeling, and (v) gap junction modulation and heart conduction. In this review, we discuss the rationale for developing TGF-β signaling-interfering therapies as adjuvant approaches for the management of the cardiac alterations of Chagas disease-affected patients.

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Year:  2012        PMID： 22990752     DOI： 10.1038/clpt.2012.102

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  26 in total

1.  Trypanosoma cruzi highjacks TrkC to enter cardiomyocytes and cardiac fibroblasts while exploiting TrkA for cardioprotection against oxidative stress.

Authors:  Daniel Aridgides; Ryan Salvador; Mercio PereiraPerrin
Journal:  Cell Microbiol       Date:  2013-03-14       Impact factor: 3.715

2.  Characterization of Trypanosoma cruzi infectivity, proliferation, and cytokine patterns in gut and pancreatic epithelial cells maintained in vitro.

Authors:  Laura A Martello; Raj Wadgaonkar; Raavi Gupta; Fabiana S Machado; Michael G Walsh; Eduardo Mascareno; Herbert B Tanowitz; M A Haseeb
Journal:  Parasitol Res       Date:  2013-09-10       Impact factor: 2.289

Review 3.  Emerging and reemerging neglected tropical diseases: a review of key characteristics, risk factors, and the policy and innovation environment.

Authors:  Tim K Mackey; Bryan A Liang; Raphael Cuomo; Ryan Hafen; Kimberly C Brouwer; Daniel E Lee
Journal:  Clin Microbiol Rev       Date:  2014-10       Impact factor: 26.132

4.  Differential cytokine profiling in Chagasic patients according to their arrhythmogenic-status.

Authors:  Héctor Rodríguez-Angulo; Juan Marques; Ivan Mendoza; Marco Villegas; Alfredo Mijares; Núria Gironès; Manuel Fresno
Journal:  BMC Infect Dis       Date:  2017-03-21       Impact factor: 3.090

Review 5.  Pathology and Pathogenesis of Chagas Heart Disease.

Authors:  Kevin M Bonney; Daniel J Luthringer; Stacey A Kim; Nisha J Garg; David M Engman
Journal:  Annu Rev Pathol       Date:  2018-10-24       Impact factor: 23.472

Review 6.  Developments in the management of Chagas cardiomyopathy.

Authors:  Herbert B Tanowitz; Fabiana S Machado; David C Spray; Joel M Friedman; Oren S Weiss; Jose N Lora; Jyothi Nagajyothi; Diego N Moraes; Nisha Jain Garg; Maria Carmo P Nunes; Antonio Luiz P Ribeiro
Journal:  Expert Rev Cardiovasc Ther       Date:  2015-10-23

7.  Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion.

Authors:  Patrícia Mello Ferrão; Claudia Masini d'Avila-Levy; Tania Cremonini Araujo-Jorge; Wim Maurits Degrave; Antônio da Silva Gonçalves; Luciana Ribeiro Garzoni; Ana Paula Lima; Jean Jacques Feige; Sabine Bailly; Leila Mendonça-Lima; Mariana Caldas Waghabi
Journal:  PLoS One       Date:  2015-05-04       Impact factor: 3.240

8.  Neuroprotective effects of SMADs in a rat model of cerebral ischemia/reperfusion.

Authors:  Fang-Fang Liu; Chao-Ying Liu; Xiao-Ping Li; Sheng-Zhe Zheng; Qing-Quan Li; Qun Liu; Lei Song
Journal:  Neural Regen Res       Date:  2015-03       Impact factor: 5.135

Review 9.  Genetic susceptibility to Chagas disease: an overview about the infection and about the association between disease and the immune response genes.

Authors:  Christiane Maria Ayo; Márcia Machado de Oliveira Dalalio; Jeane Eliete Laguila Visentainer; Pâmela Guimarães Reis; Emília Ângela Sippert; Luciana Ribeiro Jarduli; Hugo Vicentin Alves; Ana Maria Sell
Journal:  Biomed Res Int       Date:  2013-08-28       Impact factor: 3.411

10.  Dab2 attenuates brain injury in APP/PS1 mice via targeting transforming growth factor-beta/SMAD signaling.

Authors:  Lei Song; Yue Gu; Jing Jie; Xiaoxue Bai; Ying Yang; Chaoying Liu; Qun Liu
Journal:  Neural Regen Res       Date:  2014-01-01       Impact factor: 5.135
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