Literature DB >> 22990283

AlCl3 mediated unexpected migration of sulfonyl groups: regioselective synthesis of 7-sulfonyl indoles of potential pharmacological interest.

Bagineni Prasad1, Raju Adepu, Sandhya Sandra, D Rambabu, G Rama Krishna, C Malla Reddy, Girdhar Singh Deora, Parimal Misra, Manojit Pal.   

Abstract

A conceptually new and straightforward introduction of sulfonyl groups at the C-7 position of an indole ring has been achieved via AlCl(3) mediated unexpected regioselective sulfonyl group migration for N-alkyl/aryl/heteroarylsulfonyl indoles affording potential inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutase.

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Year:  2012        PMID： 22990283     DOI： 10.1039/c2cc35757g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Synthesis and biological activities of novel trifluoromethylpyridine amide derivatives containing sulfur moieties.

Authors:  S X Guo; F He; A L Dai; R F Zhang; S H Chen; J Wu
Journal:  RSC Adv       Date:  2020-09-28       Impact factor: 4.036

2.  Biological activity evaluation and action mechanism of chalcone derivatives containing thiophene sulfonate.

Authors:  Tao Guo; Rongjiao Xia; Mei Chen; Jun He; Shijun Su; Liwei Liu; Xiangyang Li; Wei Xue
Journal:  RSC Adv       Date:  2019-08-12       Impact factor: 3.361

3.  Novel isatin-indole derivatives as potential inhibitors of chorismate mutase (CM): their synthesis along with unexpected formation of 2-indolylmethylamino benzoate ester under Pd-Cu catalysis.

Authors:  Gangireddy Sujeevan Reddy; Kazi Amirul Hossain; Jetta Sandeep Kumar; B Thirupataiah; Rebecca Kristina Edwin; Varadaraj Bhat Giliyaru; Raghu Chandrashekhar Hariharapura; G Gautham Shenoy; Parimal Misra; Manojit Pal
Journal:  RSC Adv       Date:  2020-01-02       Impact factor: 4.036

Review 4.  Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents.

Authors:  Nilesh Gajanan Bajad; Sudhir Kumar Singh; Sushil Kumar Singh; Tryambak Deo Singh; Meenakshi Singh
Journal:  Curr Res Pharmacol Drug Discov       Date:  2022-07-16

5.  Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst.

Authors:  Cybille Rossy; Eric Fouquet; François-Xavier Felpin
Journal:  Beilstein J Org Chem       Date:  2013-07-16       Impact factor: 2.883
  5 in total

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