AIMS: To examine whether self-rated disease-specific and generic quality of life predicts long-term mortality, independent of brain natriuretic peptide (BNP) levels, and to explore factors related to low quality of life in a well-defined heart failure (HF) population. METHODS AND RESULTS: A cohort of 661 patients (62% male; age 71 years; left ventricular ejection fraction 34%) was followed prospectively for 3 years. Quality of life questionnaires (Ladder of Life, RAND36, and Minnesota Living with Heart Failure Questionnaire) and BNP levels were assessed at discharge after a hospital admission for HF. Three-year mortality was 42%. After adjustment for demographic variables, clinical variables, and BNP levels, poor quality of life scores predicted higher mortality; per 10 units on the physical functioning [hazard ratio (HR) 1.08, 95% confidence interval (CI) 1.02-1.14] and general health (HR 1.08, 95% CI 1.01-1.16) dimensions of the RAND36. Patients with low scores on these dimensions were more likely to be in New York Heart Association class III-IV, diagnosed with co-morbidities, have suffered longer from HF, have lower estimated glomerular filtration rates, and have fewer beta-blocker prescriptions. CONCLUSION:Quality of life was independently related to survival in a cohort of hospitalized patients with HF. TRIAL REGISTRATION: NCT 98675639.
RCT Entities:
AIMS: To examine whether self-rated disease-specific and generic quality of life predicts long-term mortality, independent of brain natriuretic peptide (BNP) levels, and to explore factors related to low quality of life in a well-defined heart failure (HF) population. METHODS AND RESULTS: A cohort of 661 patients (62% male; age 71 years; left ventricular ejection fraction 34%) was followed prospectively for 3 years. Quality of life questionnaires (Ladder of Life, RAND36, and Minnesota Living with Heart Failure Questionnaire) and BNP levels were assessed at discharge after a hospital admission for HF. Three-year mortality was 42%. After adjustment for demographic variables, clinical variables, and BNP levels, poor quality of life scores predicted higher mortality; per 10 units on the physical functioning [hazard ratio (HR) 1.08, 95% confidence interval (CI) 1.02-1.14] and general health (HR 1.08, 95% CI 1.01-1.16) dimensions of the RAND36. Patients with low scores on these dimensions were more likely to be in New York Heart Association class III-IV, diagnosed with co-morbidities, have suffered longer from HF, have lower estimated glomerular filtration rates, and have fewer beta-blocker prescriptions. CONCLUSION: Quality of life was independently related to survival in a cohort of hospitalized patients with HF. TRIAL REGISTRATION: NCT 98675639.
Authors: Andrew Sherwood; James A Blumenthal; Gary G Koch; Benson M Hoffman; Lana L Watkins; Patrick J Smith; Christopher M O'Connor; Kirkwood F Adams; Joseph G Rogers; Carla Sueta; Patricia P Chang; Kristy S Johnson; Jeanne Schwartz; Alan L Hinderliter Journal: Circ Heart Fail Date: 2017-01 Impact factor: 8.790
Authors: Roslyn A Prichard; Fei-Li Zhao; Julee Mcdonagh; Stephen Goodall; Patricia M Davidson; Phillip J Newton; Ben Farr-Wharton; Christopher S Hayward Journal: Qual Life Res Date: 2021-01-02 Impact factor: 4.147
Authors: Susan M Joseph; Eric Novak; Suzanne V Arnold; Philip G Jones; Himad Khattak; Anne E Platts; Victor G Dávila-Román; Douglas L Mann; John A Spertus Journal: Circ Heart Fail Date: 2013-10-15 Impact factor: 8.790
Authors: Michael L Alosco; Mary Beth Spitznagel; Ronald Cohen; Lawrence H Sweet; Lisa H Colbert; Richard Josephson; Joel Hughes; Jim Rosneck; John Gunstad Journal: Eur J Cardiovasc Nurs Date: 2013-06-09 Impact factor: 3.908