Literature DB >> 2298830

PAF antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus.

H Oberpichler1, D Sauer, C Rossberg, H D Mennel, J Krieglstein.   

Abstract

We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal necroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B.

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Year:  1990        PMID： 2298830     DOI： 10.1038/jcbfm.1990.17

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  21 in total

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