Literature DB >> 2298816

Basic fibroblast growth factor and transforming growth factor-alpha are hepatotrophic mitogens in vitro.

B Hoffmann1, D Paul.   

Abstract

Basic fibroblast growth factor (bFGF) and transforming growth factor-alpha (TGF alpha) have been identified as potent hepatotrophic mitogens. bFGF and TGF alpha induce DNA synthesis in fetal and adult rat hepatocytes in primary culture and support fetal rat hepatocyte multiplication in chemically defined medium. No additional exogenous growth or progression factors are required by the cells for traversing the cell cycle or for cell division. These mitogenic polypeptides, previously identified in various cell types including liver and endothelial cells, platelets, and macrophages may act locally in a paracrine mode in controlling hepatocyte multiplication in the liver during development and regeneration.

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Year:  1990        PMID： 2298816     DOI： 10.1002/jcp.1041420118

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  8 in total

1.  Effects of methylmercury on primary cultured rat hepatocytes: cell injury and inhibition of growth factor stimulated DNA synthesis.

Authors:  K Tanno; T Fukazawa; S Tajima; M Fujiki
Journal:  Bull Environ Contam Toxicol       Date:  1992-08       Impact factor: 2.151

2.  Endothelial-directed hepatic regeneration after partial hepatectomy.

Authors:  Arin K Greene; Stephen Wiener; Mark Puder; Atsushi Yoshida; Bin Shi; Antonio R Perez-Atayde; Jason A Efstathiou; Lars Holmgren; Anthony P Adamis; Maria Rupnick; Judah Folkman; Michael S O'Reilly
Journal:  Ann Surg       Date:  2003-04       Impact factor: 12.969

3.  Effect of different liver resection methods on liver damage and regeneration factors VEGF and FGF-2 in mice.

Authors:  Roderich Bönninghoff; Kay Schwenke; Michael Keese; Richard Magdeburg; Hinrich Bitter-Suermann; Mirko Otto; Till Hasenberg; Stefan Post; Jörg Sturm
Journal:  Can J Surg       Date:  2012-12       Impact factor: 2.089

4.  Tumor necrosis factor-alpha acts as a complete mitogen for primary rat hepatocytes.

Authors:  Heather A Iocca; Harriet C Isom
Journal:  Am J Pathol       Date:  2003-08       Impact factor: 4.307

5.  Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma.

Authors:  Fei Dong; Chia-Yang Liu; Yong Yuan; Yujin Zhang; Wei Li; Mindy Call; Liyun Zhang; Yongxiong Chen; Zuguo Liu; Winston W Y Kao
Journal:  Dev Biol       Date:  2015-09-10       Impact factor: 3.582

6.  Mitogenic effects of coagulation factor XII and factor XIIa on HepG2 cells.

Authors:  K T Schmeidler-Sapiro; O D Ratnoff; E M Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

7.  Facilitation by partial hepatectomy of tumor growth within the rat liver following intraportal injection of syngeneic tumor cells.

Authors:  M C Loizidou; R J Lawrance; S Holt; N J Carty; A J Cooper; P Alexander; I Taylor
Journal:  Clin Exp Metastasis       Date:  1991 Jul-Aug       Impact factor: 5.150

8.  DNA binding by C/EBP proteins correlates with hepatocyte proliferation.

Authors:  H E Soriano; T A Bilyeu; T S Juan; W Zhao; G J Darlington
Journal:  In Vitro Cell Dev Biol Anim       Date:  1995-10       Impact factor: 2.416
  8 in total

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