Literature DB >> 22987791

Synthesis and structure-activity relationships of lansine analogues as antileishmanial agents.

Marco Pieroni1, Sisay Girmay, Dianqing Sun, Rajnish Sahu, Babu L Tekwani, Ghee T Tan.   

Abstract

Clear and rational thinking: A series of rationally designed, lansine-derived carbazoles was synthesized and evaluated for activity against promastigotes and amastigotes of Leishmania donovani, the causative agent of leishmaniasis. Some structural modifications gave rise to compounds with enhanced activity and selectivity over lansine, allowing structure-activity relationships to be elucidated and providing a foundation for the further development of this pharmacophore.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Leishmania donovani; antiparasitic agents; carbazoles; drug design; leishmaniasis

Mesh：

Substances：

Year:  2012        PMID： 22987791      PMCID： PMC3565020          DOI： 10.1002/cmdc.201200346

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  28 in total

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