An Vo1, David Eidelberg, Aziz M Uluǧ. 1. Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.
Abstract
PURPOSE: To determine brain tissue affected by dystonia by making group comparison of parameter-based diffusion tensor imaging (DTI) distributions of patients with control subjects. A 2D distribution analysis of mean diffusivity and fractional anisotropy index was used for modeling brain tissues according to the inherent diffusion characteristics. MATERIALS AND METHODS: Seven affected carriers of the DYT1 dystonia mutation and eight healthy control subjects were imaged for a previous study. We employed a 2D distribution analysis of all the diffusion voxels and a four compartmental brain model for group comparison of the dystonia subjects and controls. RESULTS: Our analysis showed disease involvement in the white matter of the patients. Excellent tissue characterization was achieved automatically using the 2D distribution analysis based on a physical brain model. CONCLUSION: This 2D analysis implicated white matter in dystonia and could be useful as a screening tool in diseases with unknown pathologies.
PURPOSE: To determine brain tissue affected by dystonia by making group comparison of parameter-based diffusion tensor imaging (DTI) distributions of patients with control subjects. A 2D distribution analysis of mean diffusivity and fractional anisotropy index was used for modeling brain tissues according to the inherent diffusion characteristics. MATERIALS AND METHODS: Seven affected carriers of the DYT1dystonia mutation and eight healthy control subjects were imaged for a previous study. We employed a 2D distribution analysis of all the diffusion voxels and a four compartmental brain model for group comparison of the dystonia subjects and controls. RESULTS: Our analysis showed disease involvement in the white matter of the patients. Excellent tissue characterization was achieved automatically using the 2D distribution analysis based on a physical brain model. CONCLUSION: This 2D analysis implicated white matter in dystonia and could be useful as a screening tool in diseases with unknown pathologies.
Authors: Aziz M Uluğ; An Vo; Miklos Argyelan; Lauren Tanabe; Wynne K Schiffer; Stephen Dewey; William T Dauer; David Eidelberg Journal: Proc Natl Acad Sci U S A Date: 2011-04-04 Impact factor: 11.205
Authors: Miklos Argyelan; Maren Carbon; Martin Niethammer; Aziz M Ulug; Henning U Voss; Susan B Bressman; Vijay Dhawan; David Eidelberg Journal: J Neurosci Date: 2009-08-05 Impact factor: 6.167
Authors: J P Dyke; H U Voss; D Sondhi; N R Hackett; S Worgall; L A Heier; B E Kosofsky; A M Uluğ; D C Shungu; X Mao; R G Crystal; D Ballon Journal: AJNR Am J Neuroradiol Date: 2007-08 Impact factor: 3.825
Authors: C Tessa; M Giannelli; R Della Nave; C Lucetti; C Berti; A Ginestroni; U Bonuccelli; M Mascalchi Journal: AJNR Am J Neuroradiol Date: 2008-01-09 Impact factor: 3.825