BACKGROUND: It is widely known that atrophy of medial temporal structures is present in the mild stage of Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). However, structures such as the thalamus and corpus callosum are much less studied. METHODS: We compared the volumes of the entorhinal cortex, hippocampus, thalamus and the corpus callosum in 14 controls, 14 patients with mild AD and 15 with aMCI and correlated these volumes with neuropsychological data. MRI was obtained at 2 T followed by manual segmentation. RESULTS: We found atrophy in hippocampi and thalami of MCI patients compared to controls, and in the bilateral entorhinal cortex of aMCI compared to AD patients. All the structures showed atrophy in AD patients compared to controls, including the corpus callosum. CONCLUSIONS: Our study confirms that thalamic areas are atrophied in aMCI, and the corpus callosum might represent a good structural marker for mild AD. Those areas were associated with cognitive functions already described in the literature.
BACKGROUND: It is widely known that atrophy of medial temporal structures is present in the mild stage of Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). However, structures such as the thalamus and corpus callosum are much less studied. METHODS: We compared the volumes of the entorhinal cortex, hippocampus, thalamus and the corpus callosum in 14 controls, 14 patients with mild AD and 15 with aMCI and correlated these volumes with neuropsychological data. MRI was obtained at 2 T followed by manual segmentation. RESULTS: We found atrophy in hippocampi and thalami of MCI patients compared to controls, and in the bilateral entorhinal cortex of aMCI compared to ADpatients. All the structures showed atrophy in ADpatients compared to controls, including the corpus callosum. CONCLUSIONS: Our study confirms that thalamic areas are atrophied in aMCI, and the corpus callosum might represent a good structural marker for mild AD. Those areas were associated with cognitive functions already described in the literature.
Authors: Dejan Jakimovski; Niels Bergsland; Michael G Dwyer; Jesper Hagemeier; Deepa P Ramasamy; Kinga Szigeti; Thomas Guttuso; David Lichter; David Hojnacki; Bianca Weinstock-Guttman; Ralph H B Benedict; Robert Zivadinov Journal: Neurobiol Aging Date: 2020-02-08 Impact factor: 4.673
Authors: Thomas Alderson; Elizabeth Kehoe; Liam Maguire; Dervla Farrell; Brian Lawlor; Rose A Kenny; Declan Lyons; Arun L W Bokde; Damien Coyle Journal: Front Aging Neurosci Date: 2017-11-08 Impact factor: 5.750
Authors: Natalie S Ryan; Shiva Keihaninejad; Timothy J Shakespeare; Manja Lehmann; Sebastian J Crutch; Ian B Malone; John S Thornton; Laura Mancini; Harpreet Hyare; Tarek Yousry; Gerard R Ridgway; Hui Zhang; Marc Modat; Daniel C Alexander; Martin N Rossor; Sebastien Ourselin; Nick C Fox Journal: Brain Date: 2013-03-28 Impact factor: 13.501