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Literature DB >> 22986503

A new horizon for epigenetic medicine?

Abstract

Histone lysine demethylases are chromatin modifiers that play important roles in many pathological processes such as inflammation and cancer, making them potentially attractive drug targets. In a recent study, Kruidenier et al. provided proof of concept by identifying chemical matters that inhibit demethylation mediated by the two related histone H3 lysine 27 demethylases, KDM6A and 6B (UTX and JMJD3). The KDM6 inhibitor shows remarkable substrate selectivity and can inhibit transcription of a plethora of pro-inflammatory genes in cell culture by altering H3K27me3 level at some of the KDM6 target genes.

Entities: Chemical Disease Gene

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Year: 2012 PMID： 22986503 PMCID： PMC3587697 DOI： 10.1038/cr.2012.136

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

15 in total

1. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Authors: Damian B Yap; Justin Chu; Tobias Berg; Matthieu Schapira; S-W Grace Cheng; Annie Moradian; Ryan D Morin; Andrew J Mungall; Barbara Meissner; Merrill Boyle; Victor E Marquez; Marco A Marra; Randy D Gascoyne; R Keith Humphries; Cheryl H Arrowsmith; Gregg B Morin; Samuel A J R Aparicio
Journal: Blood Date: 2010-12-29 Impact factor: 22.113

2. A histone H3 lysine 27 demethylase regulates animal posterior development.

Authors: Fei Lan; Peter E Bayliss; John L Rinn; Johnathan R Whetstine; Jordon K Wang; Shuzhen Chen; Shigeki Iwase; Roman Alpatov; Irina Issaeva; Eli Canaani; Thomas M Roberts; Howard Y Chang; Yang Shi
Journal: Nature Date: 2007-09-12 Impact factor: 49.962

3. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder.

Authors: Yaoting Gui; Guangwu Guo; Yi Huang; Xueda Hu; Aifa Tang; Shengjie Gao; Renhua Wu; Chao Chen; Xianxin Li; Liang Zhou; Minghui He; Zesong Li; Xiaojuan Sun; Wenlong Jia; Jinnong Chen; Shangming Yang; Fangjian Zhou; Xiaokun Zhao; Shengqing Wan; Rui Ye; Chaozhao Liang; Zhisheng Liu; Peide Huang; Chunxiao Liu; Hui Jiang; Yong Wang; Hancheng Zheng; Liang Sun; Xingwang Liu; Zhimao Jiang; Dafei Feng; Jing Chen; Song Wu; Jing Zou; Zhongfu Zhang; Ruilin Yang; Jun Zhao; Congjie Xu; Weihua Yin; Zhichen Guan; Jiongxian Ye; Hong Zhang; Jingxiang Li; Karsten Kristiansen; Michael L Nickerson; Dan Theodorescu; Yingrui Li; Xiuqing Zhang; Songgang Li; Jian Wang; Huanming Yang; Jun Wang; Zhiming Cai
Journal: Nat Genet Date: 2011-08-07 Impact factor: 38.330

4. The polycomb group protein EZH2 is involved in progression of prostate cancer.

Authors: Sooryanarayana Varambally; Saravana M Dhanasekaran; Ming Zhou; Terrence R Barrette; Chandan Kumar-Sinha; Martin G Sanda; Debashis Ghosh; Kenneth J Pienta; Richard G A B Sewalt; Arie P Otte; Mark A Rubin; Arul M Chinnaiyan
Journal: Nature Date: 2002-10-10 Impact factor: 49.962

5. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.

Authors: Francesca De Santa; Maria Grazia Totaro; Elena Prosperini; Samuele Notarbartolo; Giuseppe Testa; Gioacchino Natoli
Journal: Cell Date: 2007-09-06 Impact factor: 41.582

6. Jmjd3 contributes to the control of gene expression in LPS-activated macrophages.

Authors: Francesca De Santa; Vipin Narang; Zhei Hwee Yap; Betsabeh Khoramian Tusi; Thomas Burgold; Liv Austenaa; Gabriele Bucci; Marieta Caganova; Samuele Notarbartolo; Stefano Casola; Giuseppe Testa; Wing-Kin Sung; Chia-Lin Wei; Gioacchino Natoli
Journal: EMBO J Date: 2009-09-24 Impact factor: 11.598

7. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Authors: Ryan D Morin; Nathalie A Johnson; Tesa M Severson; Andrew J Mungall; Jianghong An; Rodrigo Goya; Jessica E Paul; Merrill Boyle; Bruce W Woolcock; Florian Kuchenbauer; Damian Yap; R Keith Humphries; Obi L Griffith; Sohrab Shah; Henry Zhu; Michelle Kimbara; Pavel Shashkin; Jean F Charlot; Marianna Tcherpakov; Richard Corbett; Angela Tam; Richard Varhol; Duane Smailus; Michelle Moksa; Yongjun Zhao; Allen Delaney; Hong Qian; Inanc Birol; Jacqueline Schein; Richard Moore; Robert Holt; Doug E Horsman; Joseph M Connors; Steven Jones; Samuel Aparicio; Martin Hirst; Randy D Gascoyne; Marco A Marra
Journal: Nat Genet Date: 2010-01-17 Impact factor: 38.330

8. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.

Authors: Gillian L Dalgliesh; Kyle Furge; Chris Greenman; Lina Chen; Graham Bignell; Adam Butler; Helen Davies; Sarah Edkins; Claire Hardy; Calli Latimer; Jon Teague; Jenny Andrews; Syd Barthorpe; Dave Beare; Gemma Buck; Peter J Campbell; Simon Forbes; Mingming Jia; David Jones; Henry Knott; Chai Yin Kok; King Wai Lau; Catherine Leroy; Meng-Lay Lin; David J McBride; Mark Maddison; Simon Maguire; Kirsten McLay; Andrew Menzies; Tatiana Mironenko; Lee Mulderrig; Laura Mudie; Sarah O'Meara; Erin Pleasance; Arjunan Rajasingham; Rebecca Shepherd; Raffaella Smith; Lucy Stebbings; Philip Stephens; Gurpreet Tang; Patrick S Tarpey; Kelly Turrell; Karl J Dykema; Sok Kean Khoo; David Petillo; Bill Wondergem; John Anema; Richard J Kahnoski; Bin Tean Teh; Michael R Stratton; P Andrew Futreal
Journal: Nature Date: 2010-01-06 Impact factor: 49.962

9. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

Authors: Gijs van Haaften; Gillian L Dalgliesh; Helen Davies; Lina Chen; Graham Bignell; Chris Greenman; Sarah Edkins; Claire Hardy; Sarah O'Meara; Jon Teague; Adam Butler; Jonathan Hinton; Calli Latimer; Jenny Andrews; Syd Barthorpe; Dave Beare; Gemma Buck; Peter J Campbell; Jennifer Cole; Simon Forbes; Mingming Jia; David Jones; Chai Yin Kok; Catherine Leroy; Meng-Lay Lin; David J McBride; Mark Maddison; Simon Maquire; Kirsten McLay; Andrew Menzies; Tatiana Mironenko; Lee Mulderrig; Laura Mudie; Erin Pleasance; Rebecca Shepherd; Raffaella Smith; Lucy Stebbings; Philip Stephens; Gurpreet Tang; Patrick S Tarpey; Rachel Turner; Kelly Turrell; Jennifer Varian; Sofie West; Sara Widaa; Paul Wray; V Peter Collins; Koichi Ichimura; Simon Law; John Wong; Siu Tsan Yuen; Suet Yi Leung; Giovanni Tonon; Ronald A DePinho; Yu-Tzu Tai; Kenneth C Anderson; Richard J Kahnoski; Aaron Massie; Sok Kean Khoo; Bin Tean Teh; Michael R Stratton; P Andrew Futreal
Journal: Nat Genet Date: 2009-03-29 Impact factor: 38.330

10. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Authors: Laurens Kruidenier; Chun-wa Chung; Zhongjun Cheng; John Liddle; KaHing Che; Gerard Joberty; Marcus Bantscheff; Chas Bountra; Angela Bridges; Hawa Diallo; Dirk Eberhard; Sue Hutchinson; Emma Jones; Roy Katso; Melanie Leveridge; Palwinder K Mander; Julie Mosley; Cesar Ramirez-Molina; Paul Rowland; Christopher J Schofield; Robert J Sheppard; Julia E Smith; Catherine Swales; Robert Tanner; Pamela Thomas; Anthony Tumber; Gerard Drewes; Udo Oppermann; Dinshaw J Patel; Kevin Lee; David M Wilson
Journal: Nature Date: 2012-08-16 Impact factor: 49.962

6 in total

A new horizon for epigenetic medicine?

1. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

2. A histone H3 lysine 27 demethylase regulates animal posterior development.

3. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder.

4. The polycomb group protein EZH2 is involved in progression of prostate cancer.

5. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.

6. Jmjd3 contributes to the control of gene expression in LPS-activated macrophages.

7. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

8. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.

9. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

10. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Review 1. Epigenetic Regulation of Dendritic Cell Development and Function.

2. Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix.

3. Decreased expression of JMJD3 predicts poor prognosis of patients with clear cell renal cell carcinoma.

4. Zoledronic acid regulates the synthesis and secretion of IL-1β through Histone methylation in macrophages.

Review 5. Methylation in HOX Clusters and Its Applications in Cancer Therapy.

6. Epigenetic Heterogeneity of B-Cell Lymphoma: Chromatin Modifiers.