Jin Gu Kang1, Myung Hee Kim, Eun Hee Kim, Sang Hyun Lee. 1. Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul, Korea.
Abstract
STUDY OBJECTIVE: To evaluate whether intraoperative low-dose lidocaine infusion decreases postoperative analgesic consumption, ileus, and duration of hospital stay. DESIGN: Prospective, randomized, double-blinded trial. SETTING: Operating room in a university hospital. PATIENTS: 48 ASA physical status 1 and 2 men scheduled forsubtotal gastrectomy. INTERVENTIONS: Patients were randomly allocated to two groups to receive either intravenous (IV) lidocaine 1.5 mg/kg 20 minutes before incision followed by a continuous lidocaine infusion of 1.5 mg/kg/hr until the end of surgery (lidocaine group) or saline in a similar manner (control group). MEASUREMENTS: Outcomes such as pain intensity, postoperative analgesic consumption, duration of ileus, and hospital length of stay (LOS) were recorded. MAIN RESULTS: There were no differences in total consumption of IV patient-controlled analgesia (IVPCA) or pain scores at 24, 48, or 72 hours postoperatively. However, lidocaine group patients had significantly decreased average supplemental pethidine requirement per patient for pain control until 72 hours postoperatively [150 (75-200) mg vs 50 (50-150) mg, P = 0.039] and hospital LOS (9.5 ± 3 d vs 8.7 ± 1 d, P = 0.006, 95% CI: - 0.3 - 1.9 d) than control group patients. However, no differences were noted between the groups in pain intensity or duration of ileus. CONCLUSIONS:Intraoperative IV low-dose lidocaine infusion decreased opioid consumption and hospital LOS after gastrectomy.
RCT Entities:
STUDY OBJECTIVE: To evaluate whether intraoperative low-dose lidocaine infusion decreases postoperative analgesic consumption, ileus, and duration of hospital stay. DESIGN: Prospective, randomized, double-blinded trial. SETTING: Operating room in a university hospital. PATIENTS: 48 ASA physical status 1 and 2 men scheduled for subtotal gastrectomy. INTERVENTIONS:Patients were randomly allocated to two groups to receive either intravenous (IV) lidocaine 1.5 mg/kg 20 minutes before incision followed by a continuous lidocaine infusion of 1.5 mg/kg/hr until the end of surgery (lidocaine group) or saline in a similar manner (control group). MEASUREMENTS: Outcomes such as pain intensity, postoperative analgesic consumption, duration of ileus, and hospital length of stay (LOS) were recorded. MAIN RESULTS: There were no differences in total consumption of IV patient-controlled analgesia (IVPCA) or pain scores at 24, 48, or 72 hours postoperatively. However, lidocaine group patients had significantly decreased average supplemental pethidine requirement per patient for pain control until 72 hours postoperatively [150 (75-200) mg vs 50 (50-150) mg, P = 0.039] and hospital LOS (9.5 ± 3 d vs 8.7 ± 1 d, P = 0.006, 95% CI: - 0.3 - 1.9 d) than control group patients. However, no differences were noted between the groups in pain intensity or duration of ileus. CONCLUSIONS: Intraoperative IV low-dose lidocaine infusion decreased opioid consumption and hospital LOS after gastrectomy.
Authors: Anne Marie Sowerbutts; Stephen R Knight; Marie Carmela M Lapitan; Ahmad U Qureshi; Mayaba Maimbo; Edwin Mwintiereh Ta-Ang Yenli; Stephen Tabiri; Dhruva Ghosh; Pamela Alice Kingsley; Sudha Sundar; Catherine A Shaw; Apple Valparaiso; Cristina Almira Alviz; Aneel Bhangu; Evropi Theodoratou; Thomas G Weiser; Ewen M Harrison; Sorrel T Burden Journal: Nutrients Date: 2022-02-18 Impact factor: 5.717
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