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Literature DB >> 22985294

Nanostructured thin film polymer devices for constant-rate protein delivery.

Daniel A Bernards¹, Kevin D Lance, Natalie A Ciaccio, Tejal A Desai.

Abstract

Herein long-term delivery of proteins from biodegradable thin film devices is demonstrated, where a nanostructured polymer membrane controls release. Protein was sealed between two poly(caprolactone) films, which generated the thin film devices. Protein release for 210 days was shown in vitro, and stable activity was established through 70 days with a model protein. These thin film devices present a promising delivery platform for biologic therapeutics, particularly for application in constrained spaces.

Entities: Chemical Disease Species

Mesh：

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Year: 2012 PMID： 22985294 PMCID： PMC3480309 DOI： 10.1021/nl302747y

Source DB: PubMed Journal: Nano Lett ISSN： 1530-6984 Impact factor: 11.189

28 in total

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Review 2. Recent advances in intraocular sustained-release drug delivery devices.

Authors: Yiqi Cao; Karen E Samy; Daniel A Bernards; Tejal A Desai
Journal: Drug Discov Today Date: 2019-06-04 Impact factor: 7.851

3. Stimuli-responsive theragrippers for chemomechanical controlled release.

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4. Supporting Survival of Transplanted Stem-Cell-Derived Insulin-Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids.

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5. Polycaprolactone thin-film drug delivery systems: Empirical and predictive models for device design.

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Journal: Mater Sci Eng C Mater Biol Appl Date: 2015-08-01 Impact factor: 7.328

6. In vivo and in vitro sustained release of ranibizumab from a nanoporous thin-film device.

Authors: Kevin D Lance; Daniel A Bernards; Natalie A Ciaccio; Samuel D Good; Thaís S Mendes; Max Kudisch; Elliot Chan; Mynna Ishikiriyama; Robert B Bhisitkul; Tejal A Desai
Journal: Drug Deliv Transl Res Date: 2016-12 Impact factor: 4.617

7. Polycaprolactone Thin-Film Micro- and Nanoporous Cell-Encapsulation Devices.

Authors: Crystal E Nyitray; Ryan Chang; Gaetano Faleo; Kevin D Lance; Daniel A Bernards; Qizhi Tang; Tejal A Desai
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10. In Vitro and In Vivo Sustained Zero-Order Delivery of Rapamycin (Sirolimus) From a Biodegradable Intraocular Device.

Authors: Kevin D Lance; Samuel D Good; Thaís S Mendes; Mynna Ishikiriyama; Patrick Chew; Laurel S Estes; Kazuhito Yamada; Sri Mudumba; Robert B Bhisitkul; Tejal A Desai
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