INTRODUCTION: The pathogenesis of circumscribed palmar hypokeratosis (CPH) is still controversial, and to date there is no treatment of choice. METHODS: We report on a patient with CPH responding to treatment with fluorouracil cream. RESULTS: The clinical course and histopathological features in our observation point towards the possibility of an underlying squamous cell carcinoma in situ presenting as CPH. CONCLUSION: We suggest that fluorouracil cream treatment should be considered as a therapeutic option in cases of CPH.
INTRODUCTION: The pathogenesis of circumscribed palmar hypokeratosis (CPH) is still controversial, and to date there is no treatment of choice. METHODS: We report on a patient with CPH responding to treatment with fluorouracil cream. RESULTS: The clinical course and histopathological features in our observation point towards the possibility of an underlying squamous cell carcinoma in situ presenting as CPH. CONCLUSION: We suggest that fluorouracil cream treatment should be considered as a therapeutic option in cases of CPH.
Authors: Amparo Pérez; Arno Rütten; Reinhard Gold; Francisco Urbina; Carlos Misad; Maria José Izquierdo; Celia Requena; Adolfo Aliaga; Heinz Kutzner; Luis Requena Journal: J Am Acad Dermatol Date: 2002-07 Impact factor: 11.527
Authors: David R Berk; Almut Böer; Fred D Bauschard; Mark A Hurt; Daniel J Santa-Cruz; Arthur Z Eisen Journal: J Am Acad Dermatol Date: 2007-04-06 Impact factor: 11.527