Literature DB >> 2298446

Cloning and sequence analysis of the human parathyroid hormone gene region.

A Reis1, W Hecht, R Gröger, I Böhm, D N Cooper, W Lindenmaier, H Mayer, J Schmidtke.   

Abstract

A region of 50 kb around the human PTH gene was cloned and mapped by restriction analysis. Sequence analysis was performed and 3270bp determined, completing the sequence of the gene. The nucleotide sequence was analysed with regard to homology between human, bovine and rat PTH genes, and various potential cis-acting regulatory elements were identified. The gene region lacks an obvious CpG island. The PTH gene region in patients suffering from (pseudo)-hypoparathyroidism was investigated by Southern blotting. No detectable alteration in the fragment patterns was observed. Results of segregation analysis in families with affected individuals was inconclusive.

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Year:  1990        PMID： 2298446     DOI： 10.1007/bf00208924

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  33 in total

1.  Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene.

Authors:  B J Graves; P F Johnson; S L McKnight
Journal:  Cell       Date:  1986-02-28       Impact factor: 41.582

2.  Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone.

Authors:  H M Kronenberg; B E McDevitt; J A Majzoub; J Nathans; P A Sharp; J T Potts; A Rich
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

Review 3.  Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

Authors:  N C Jones; P W Rigby; E B Ziff
Journal:  Genes Dev       Date:  1988-03       Impact factor: 11.361

4.  Familial isolated hypoparathyroidism: a molecular genetic analysis of 8 families with 23 affected persons.

Authors:  T G Ahn; S E Antonarakis; H M Kronenberg; T Igarashi; M A Levine
Journal:  Medicine (Baltimore)       Date:  1986-03       Impact factor: 1.889

5.  Chromosome mapping of genes on the short arm of human chromosome 11: parathyroid hormone gene is at 11p15 together with the genes for insulin, c-Harvey-ras 1, and beta-hemoglobin.

Authors:  B U Zabel; H M Kronenberg; G I Bell; T B Shows
Journal:  Cytogenet Cell Genet       Date:  1985

6.  Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone.

Authors:  G Heinrich; H M Kronenberg; J T Potts; J F Habener
Journal:  J Biol Chem       Date:  1984-03-10       Impact factor: 5.157

7.  Isolation and complete nucleotide sequence of the gene for bovine parathyroid hormone.

Authors:  C A Weaver; D F Gordon; M S Kissil; D A Mead; B Kemper
Journal:  Gene       Date:  1984-06       Impact factor: 3.688

8.  The loci for parathyroid hormone and beta-globin are closely linked and map to chromosome 15 in cattle.

Authors:  R Fries; R Hediger; G Stranzinger
Journal:  Genomics       Date:  1988-11       Impact factor: 5.736

9.  Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells.

Authors:  J Silver; J Russell; L M Sherwood
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

10.  Human parathyroid hormone gene (PTH) is on short arm of chromosome 11.

Authors:  S L Naylor; A Y Sakaguchi; P Szoka; G N Hendy; H M Kronenberg; A Rich; T B Shows
Journal:  Somatic Cell Genet       Date:  1983-09
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  4 in total

1.  Novel PTH Gene Mutations Causing Isolated Hypoparathyroidism.

Authors:  Colin P Hawkes; Jamal M Al Jubeh; Dong Li; Susan E Tucker; Tara Rajiyah; Michael A Levine
Journal:  J Clin Endocrinol Metab       Date:  2022-05-17       Impact factor: 6.134

2.  Parathyroid hormone gene analysis in autosomal hypoparathyroidism using an intragenic tetranucleotide (AAAT)n polymorphism.

Authors:  D B Parkinson; N J Shaw; R L Himsworth; R V Thakker
Journal:  Hum Genet       Date:  1993-04       Impact factor: 4.132

3.  Characterization of two novel polymorphisms at the human parathyroid hormone gene locus.

Authors:  J E Mullersman; J J Shields; B K Saha
Journal:  Hum Genet       Date:  1992-03       Impact factor: 4.132

4.  The promoter of the human parathyroid hormone gene contains a functional cyclic AMP-response element.

Authors:  E Rupp; H Mayer; E Wingender
Journal:  Nucleic Acids Res       Date:  1990-10-11       Impact factor: 16.971
  4 in total

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