Literature DB >> 22983423

FGF23 production by osteocytes.

Lynda F Bonewald1, Michael J Wacker.   

Abstract

Fibroblast growth factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease. Associations between serum FGF23 level and vascular dysfunction, vascular calcification, and increased risk of cardiovascular disease have also been observed. In this review we discuss FGF23 expression in osteocytes and the potential means to regulate expression and function of this protein at the osteocyte level.

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Year:  2012        PMID： 22983423      PMCID： PMC3582753          DOI： 10.1007/s00467-012-2309-3

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  55 in total

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Authors:  Christian Faul; Ansel P Amaral; Behzad Oskouei; Ming-Chang Hu; Alexis Sloan; Tamara Isakova; Orlando M Gutiérrez; Robier Aguillon-Prada; Joy Lincoln; Joshua M Hare; Peter Mundel; Azorides Morales; Julia Scialla; Michael Fischer; Elsayed Z Soliman; Jing Chen; Alan S Go; Sylvia E Rosas; Lisa Nessel; Raymond R Townsend; Harold I Feldman; Martin St John Sutton; Akinlolu Ojo; Crystal Gadegbeku; Giovana Seno Di Marco; Stefan Reuter; Dominik Kentrup; Klaus Tiemann; Marcus Brand; Joseph A Hill; Orson W Moe; Makoto Kuro-O; John W Kusek; Martin G Keane; Myles Wolf
Journal:  J Clin Invest       Date:  2011-10-10       Impact factor: 14.808

2.  Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.

Authors:  Emily G Farrow; Xijie Yu; Lelia J Summers; Siobhan I Davis; James C Fleet; Matthew R Allen; Alexander G Robling; Keith R Stayrook; Victoria Jideonwo; Martin J Magers; Holly J Garringer; Ruben Vidal; Rebecca J Chan; Charles B Goodwin; Siu L Hui; Munro Peacock; Kenneth E White
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-17       Impact factor: 11.205

3.  Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo.

Authors:  Stacey M Woo; Jennifer Rosser; Vladimir Dusevich; Ivo Kalajzic; Lynda F Bonewald
Journal:  J Bone Miner Res       Date:  2011-11       Impact factor: 6.741

4.  Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4.

Authors:  Jyothsna Gattineni; Katherine Twombley; Regina Goetz; Moosa Mohammadi; Michel Baum
Journal:  Am J Physiol Renal Physiol       Date:  2011-05-11

5.  Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study.

Authors:  Orlando M Gutiérrez; Myles Wolf; Eric N Taylor
Journal:  Clin J Am Soc Nephrol       Date:  2011-10-27       Impact factor: 8.237

Review 6.  Clinical practice. Fibroblast growth factor (FGF)23: a new hormone.

Authors:  Uri S Alon
Journal:  Eur J Pediatr       Date:  2010-12-31       Impact factor: 3.183

7.  Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease.

Authors:  Martin H de Borst; Marc G Vervloet; Piet M ter Wee; Gerjan Navis
Journal:  J Am Soc Nephrol       Date:  2011-08-18       Impact factor: 10.121

8.  Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling women.

Authors:  Mansi Dalal; Kai Sun; Anne R Cappola; Luigi Ferrucci; Candace Crasto; Linda P Fried; Richard D Semba
Journal:  Eur J Endocrinol       Date:  2011-08-26       Impact factor: 6.664

9.  Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling.

Authors:  Aline Martin; Shiguang Liu; Valentin David; Hua Li; Anastasios Karydis; Jian Q Feng; L Darryl Quarles
Journal:  FASEB J       Date:  2011-04-20       Impact factor: 5.191

10.  Unique roles of phosphorus in endochondral bone formation and osteocyte maturation.

Authors:  Rong Zhang; Yongbo Lu; Ling Ye; Baozhi Yuan; Shibin Yu; Chunlin Qin; Yixia Xie; Tian Gao; Marc K Drezner; Lynda F Bonewald; Jian Q Feng
Journal:  J Bone Miner Res       Date:  2011-05       Impact factor: 6.741
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  45 in total

Review 1.  The past 10 years-new hormones, new functions, new endocrine organs.

Authors:  Roger Bouillon; Daniel J Drucker; Ele Ferrannini; Steven Grinspoon; Clifford J Rosen; Paul Zimmet
Journal:  Nat Rev Endocrinol       Date:  2015-09-01       Impact factor: 43.330

Review 2.  Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters.

Authors:  Ming Chang Hu; Mingjun Shi; Orson W Moe
Journal:  Pflugers Arch       Date:  2018-12-01       Impact factor: 3.657

3.  Physiology of Mechanotransduction: How Do Muscle and Bone "Talk" to One Another?

Authors:  Janalee Isaacson; Marco Brotto
Journal:  Clin Rev Bone Miner Metab       Date:  2014-06

4.  A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23.

Authors:  Qing He; Lauren T Shumate; Julia Matthias; Cumhur Aydin; Marc N Wein; Jordan M Spatz; Regina Goetz; Moosa Mohammadi; Antonius Plagge; Paola Divieti Pajevic; Murat Bastepe
Journal:  JCI Insight       Date:  2019-09-05

5.  The osteoblast to osteocyte transition: epigenetic changes and response to the vitamin D3 hormone.

Authors:  Hillary C St John; Kathleen A Bishop; Mark B Meyer; Nancy A Benkusky; Ning Leng; Christina Kendziorski; Lynda F Bonewald; J Wesley Pike
Journal:  Mol Endocrinol       Date:  2014-05-30

6.  Fibroblast growth factor 23 does not directly influence skeletal muscle cell proliferation and differentiation or ex vivo muscle contractility.

Authors:  Keith G Avin; Julian A Vallejo; Neal X Chen; Kun Wang; Chad D Touchberry; Marco Brotto; Sarah L Dallas; Sharon M Moe; Michael J Wacker
Journal:  Am J Physiol Endocrinol Metab       Date:  2018-03-20       Impact factor: 4.310

7.  Oral vitamin D3 supplementation increases serum fibroblast growth factor 23 concentration in vitamin D-deficient patients: a systematic review and meta-analysis.

Authors:  N Charoenngam; P Rujirachun; M F Holick; P Ungprasert
Journal:  Osteoporos Int       Date:  2019-08-01       Impact factor: 4.507

Review 8.  Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth).

Authors:  Stacey Fossey; John Vahle; Philip Long; Scott Schelling; Heinrich Ernst; Rogely Waite Boyce; Jacquelin Jolette; Brad Bolon; Alison Bendele; Matthias Rinke; Laura Healy; Wanda High; Daniel Robert Roth; Michael Boyle; Joel Leininger
Journal:  J Toxicol Pathol       Date:  2016-07-29       Impact factor: 1.628

9.  Functional heterogeneity of osteocytes in FGF23 production: the possible involvement of DMP1 as a direct negative regulator.

Authors:  Ji-Won Lee; Akira Yamaguchi; Tadahiro Iimura
Journal:  Bonekey Rep       Date:  2014-06-04

10.  FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy.

Authors:  Chad D Touchberry; Troy M Green; Vladimir Tchikrizov; Jaimee E Mannix; Tiffany F Mao; Brandon W Carney; Magdy Girgis; Robert J Vincent; Lori A Wetmore; Buddhadeb Dawn; Lynda F Bonewald; Jason R Stubbs; Michael J Wacker
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-02-26       Impact factor: 4.310
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