Literature DB >> 22982767

Measuring the modulus of silicone hydrogel contact lenses.

Caleb R Horst1, Benjamin Brodland, Lyndon W Jones, G Wayne Brodland.   

Abstract

PURPOSE: The purpose of this study is to demonstrate a novel method for measuring the modulus of contact lenses in their as-received, variable-thickness form and to determine whether modulus varies with location within commercial lenses and whether it is dependent on lens geometry and temperature.
METHODS: The thickness profiles of lenses having powers from -8 diopters (D) to +4 D were measured using a Rehder electronic thickness gauge. Strip-shaped specimens having a width of 5.5 mm were then cut from the lenses. Graphite particles were sprinkled on the specimen surface so that its motions could be tracked using digital image-correlation techniques. The specimens were mounted in a BioTester test system using BioRakes (rather than clamps) and stretched uniaxially until all parts of the lens between the attachment points had elongated by at least 10%. This procedure allowed local modulus values to be determined at 110 locations over the surface of each lens and any property variations within the lenses to be characterized. Tests were performed at 5, 23, and 37°C.
RESULTS: Material modulus was found to be essentially constant within any given lens and was independent of the optical power of the lens. Young's Modulus values ranged from 0.3 to 1.9 MPa, depending on the lens manufacturer and product, and some lens materials showed a decrease in modulus with temperature. For the materials tested, those with lower water content had a tendency to exhibit higher moduli.
CONCLUSIONS: Testing of the kind reported here is important for assessing the efficacy of current and proposed contact lens materials and designs, especially if such designs make use of variable properties to enhance function or fit.

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Year:  2012        PMID: 22982767     DOI: 10.1097/OPX.0b013e3182691454

Source DB:  PubMed          Journal:  Optom Vis Sci        ISSN: 1040-5488            Impact factor:   1.973


  6 in total

1.  Fabricating customized hydrogel contact lens.

Authors:  Andre Childs; Hao Li; Daniella M Lewittes; Biqin Dong; Wenzhong Liu; Xiao Shu; Cheng Sun; Hao F Zhang
Journal:  Sci Rep       Date:  2016-10-17       Impact factor: 4.379

2.  Effect of a Cationic Surfactant on Microemulsion Globules and Drug Release from Hydrogel Contact Lenses.

Authors:  Cesar Torres-Luna; Naiping Hu; Abdollah Koolivand; Xin Fan; Yuli Zhu; Roman Domszy; Jeff Yang; Arthur Yang; Nam Sun Wang
Journal:  Pharmaceutics       Date:  2019-06-06       Impact factor: 6.321

3.  Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium.

Authors:  Rachasit Jeencham; Manote Sutheerawattananonda; Saowaluk Rungchang; Waree Tiyaboonchai
Journal:  Drug Deliv       Date:  2020-12       Impact factor: 6.419

4.  Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance.

Authors:  María Vivero-Lopez; Andrea Muras; Diana Silva; Ana Paula Serro; Ana Otero; Angel Concheiro; Carmen Alvarez-Lorenzo
Journal:  Pharmaceutics       Date:  2021-04-11       Impact factor: 6.321

5.  Formation of Drug-Participating Catanionic Aggregates for Extended Delivery of Non-Steroidal Anti-Inflammatory Drugs from Contact Lenses.

Authors:  Cesar Torres-Luna; Abdollah Koolivand; Xin Fan; Niti R Agrawal; Naiping Hu; Yuli Zhu; Roman Domszy; Robert M Briber; Nam Sun Wang; Arthur Yang
Journal:  Biomolecules       Date:  2019-10-10

6.  Controlled Release of Multiple Therapeutics From Silicone Hydrogel Contact Lenses for Post-Cataract/Post-Refractive Surgery and Uveitis Treatment.

Authors:  Stephen A DiPasquale; Biaggio Uricoli; Matthew C DiCerbo; Thea L Brown; Mark E Byrne
Journal:  Transl Vis Sci Technol       Date:  2021-12-01       Impact factor: 3.283

  6 in total

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