INTRODUCTION: Dopamine is one among several neurotransmitters that regulate food intake and overeating. Thus, it has been linked to the pathophysiology of obesity and high body mass index (BMI). Striatal dopamine D(2) receptor availability is lower in obesity and there are indications that striatal dopamine transporter (DAT) availability is also decreased. In this study, we tested whether BMI and striatal DAT availability are associated. METHODS: The study included 123 healthy individuals from a large European multi-center database. They had a BMI range of 18.2-41.1 kg/m(2) and were scanned using [(123)I]FP-CIT SPECT imaging. Scans were analyzed with both region-of-interest and voxel-based analysis to determine the binding potential for DAT availability in the caudate nucleus and putamen. A direct relation between BMI and DAT availability was assessed and groups with high and low BMI were compared for DAT availability. RESULTS: No association between BMI and striatal DAT availability was found. CONCLUSION: The lack of an association between BMI and striatal DAT availability suggests that the regulation of striatal synaptic dopamine levels by DAT plays no or a limited role in the pathophysiology of overweight and obesity.
INTRODUCTION:Dopamine is one among several neurotransmitters that regulate food intake and overeating. Thus, it has been linked to the pathophysiology of obesity and high body mass index (BMI). Striatal dopamine D(2) receptor availability is lower in obesity and there are indications that striatal dopamine transporter (DAT) availability is also decreased. In this study, we tested whether BMI and striatal DAT availability are associated. METHODS: The study included 123 healthy individuals from a large European multi-center database. They had a BMI range of 18.2-41.1 kg/m(2) and were scanned using [(123)I]FP-CIT SPECT imaging. Scans were analyzed with both region-of-interest and voxel-based analysis to determine the binding potential for DAT availability in the caudate nucleus and putamen. A direct relation between BMI and DAT availability was assessed and groups with high and low BMI were compared for DAT availability. RESULTS: No association between BMI and striatal DAT availability was found. CONCLUSION: The lack of an association between BMI and striatal DAT availability suggests that the regulation of striatal synaptic dopamine levels by DAT plays no or a limited role in the pathophysiology of overweight and obesity.
Authors: Chiang-shan R Li; Marc N Potenza; Dianne E Lee; Beata Planeta; Jean-Dominique Gallezot; David Labaree; Shannan Henry; Nabeel Nabulsi; Rajita Sinha; Yu-Shin Ding; Richard E Carson; Alexander Neumeister Journal: Neuroimage Date: 2013-10-10 Impact factor: 6.556
Authors: D Salas-Gonzalez; Juan M Górriz; Javier Ramírez; Ignacio A Illán; Pablo Padilla; Francisco J Martínez-Murcia; Elmar W Lang Journal: Neuroinformatics Date: 2015-10
Authors: Swen Hesse; Georg-Alexander Becker; Michael Rullmann; Anke Bresch; Julia Luthardt; Mohammed K Hankir; Franziska Zientek; Georg Reißig; Marianne Patt; Katrin Arelin; Donald Lobsien; Ulrich Müller; S Baldofski; Philipp M Meyer; Matthias Blüher; Mathias Fasshauer; Wiebke K Fenske; Michael Stumvoll; Anja Hilbert; Yu-Shin Ding; Osama Sabri Journal: Eur J Nucl Med Mol Imaging Date: 2017-01-09 Impact factor: 9.236
Authors: D Val-Laillet; E Aarts; B Weber; M Ferrari; V Quaresima; L E Stoeckel; M Alonso-Alonso; M Audette; C H Malbert; E Stice Journal: Neuroimage Clin Date: 2015-03-24 Impact factor: 4.881
Authors: Helen Schmitz-Steinkrüger; Catharina Lange; Ivayla Apostolova; Franziska L Mathies; Lars Frings; Susanne Klutmann; Sabine Hellwig; Philipp T Meyer; Ralph Buchert Journal: Eur J Nucl Med Mol Imaging Date: 2020-10-31 Impact factor: 9.236
Authors: Fernando Caravaggio; Carol Borlido; Margaret Hahn; Zhe Feng; Gagan Fervaha; Philip Gerretsen; Shinichiro Nakajima; Eric Plitman; Jun Ku Chung; Yusuke Iwata; Alan Wilson; Gary Remington; Ariel Graff-Guerrero Journal: Int J Neuropsychopharmacol Date: 2015-02-25 Impact factor: 5.176