Literature DB >> 22981828

HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design.

Mattia Bonsignori1, S Munir Alam, Hua-Xin Liao, Laurent Verkoczy, Georgia D Tomaras, Barton F Haynes, M Anthony Moody.   

Abstract

Attempts to formulate a protective HIV-1 vaccine through classic vaccine design strategies have not been successful. Elicitation of HIV-1-specific broadly neutralizing antibodies (bnAbs) at high titers that are present before exposure might be required to achieve protection. Recently, the application of new technologies has facilitated the study of clonal lineages of HIV-1 envelope (Env) antibodies, which have provided insights into HIV-1 antibody development during infection and upon vaccination. Strategies are being developed for the analysis of infection and vaccine candidate-induced antibodies, their gene usage, and their maturation pathways such that this information can be used to attempt to guide rational vaccine design.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22981828      PMCID： PMC3757512          DOI： 10.1016/j.tim.2012.08.011

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  85 in total

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3.  Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation.

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8.  Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting.

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9.  Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated.

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Journal:  J Exp Med       Date:  2011-10-10       Impact factor: 14.307

10.  Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41.

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Journal:  PLoS One       Date:  2011-11-30       Impact factor: 3.240
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  41 in total

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10.  A novel rabbit monoclonal antibody platform to dissect the diverse repertoire of antibody epitopes for HIV-1 Env immunogen design.

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