INTRODUCTION: Atrial fibrillation (AF) is associated with impaired coronary flow by means of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC). Mean platelet volume (MPV) is elevated in patients with AF. In the present study we aimed to investigate the relationship between MPV and TFC in patients with AF in the absence of obstructive coronary artery disease (CAD). METHODS: This observational study enrolled 185 AF patients and 189 control subjects, all with angiographically documented normal coronary arteries. MPV was measured at baseline and mean TFC was assessed after diagnostic coronary angiography. RESULTS: The MPV was 9.95±1.32 in the AF group and 9.02±1.16 in the control group (p<0.001). In AF patients, MPV was significantly correlated with mean TFC (r=0.419, p<0.001), AF duration (r=0.407, p<0.001), AF classification (r=0.378, p<0.001), systemic hypertension (r=0.165, p=0.024), diabetes mellitus (r=0.233, p=0.001), left ventricular ejection fraction (r=-0.347, p<0.001), and baseline use of diuretics (r=0.177, p=0.016). In linear regression analysis, mean TFC, left ventricular ejection fraction and diabetes mellitus were found to be independently associated with MPV (p<0.001, p=0.028 and p=0.045 respectively). CONCLUSION: Mean platelet volume seems to be independently associated with coronary blood flow in patients with atrial fibrillation in the absence of obstructive coronary artery disease.
INTRODUCTION:Atrial fibrillation (AF) is associated with impaired coronary flow by means of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC). Mean platelet volume (MPV) is elevated in patients with AF. In the present study we aimed to investigate the relationship between MPV and TFC in patients with AF in the absence of obstructive coronary artery disease (CAD). METHODS: This observational study enrolled 185 AFpatients and 189 control subjects, all with angiographically documented normal coronary arteries. MPV was measured at baseline and mean TFC was assessed after diagnostic coronary angiography. RESULTS: The MPV was 9.95±1.32 in the AF group and 9.02±1.16 in the control group (p<0.001). In AFpatients, MPV was significantly correlated with mean TFC (r=0.419, p<0.001), AF duration (r=0.407, p<0.001), AF classification (r=0.378, p<0.001), systemic hypertension (r=0.165, p=0.024), diabetes mellitus (r=0.233, p=0.001), left ventricular ejection fraction (r=-0.347, p<0.001), and baseline use of diuretics (r=0.177, p=0.016). In linear regression analysis, mean TFC, left ventricular ejection fraction and diabetes mellitus were found to be independently associated with MPV (p<0.001, p=0.028 and p=0.045 respectively). CONCLUSION: Mean platelet volume seems to be independently associated with coronary blood flow in patients with atrial fibrillation in the absence of obstructive coronary artery disease.
Authors: Na Wu; Shifei Tong; Ying Xiang; Long Wu; Bin Xu; Yao Zhang; Xiangyu Ma; Yafei Li; Zhiyuan Song; Li Zhong Journal: PLoS One Date: 2015-04-17 Impact factor: 3.240
Authors: Alexander Weymann; Sadeq Ali-Hasan-Al-Saegh; Anton Sabashnikov; Aron-Frederik Popov; Seyed Jalil Mirhosseini; Tong Liu; Mohammadreza Lotfaliani; Michel Pompeu Barros de Oliveira Sá; William L L Baker; Senol Yavuz; Mohamed Zeriouh; Jae-Sik Jang; Hamidreza Dehghan; Lei Meng; Luca Testa; Fabrizio D'Ascenzo; Umberto Benedetto; Gary Tse; Luis Nombela-Franco; Pascal M Dohmen; Abhishek J Deshmukh; Cecilia Linde; Giuseppe Biondi-Zoccai; Gregg W Stone; Hugh Calkins; Integrated Meta-Analysis Of Cardiac Surgery And Cardiology-Group Imcsc-Group Journal: Med Sci Monit Basic Res Date: 2017-05-12
Authors: Alexander Weymann; Sadeq Ali-Hasan-Al-Saegh; Anton Sabashnikov; Aron-Frederik Popov; Seyed Jalil Mirhosseini; Luis Nombela-Franco; Luca Testa; Mohammadreza Lotfaliani; Mohamed Zeriouh; Tong Liu; Hamidreza Dehghan; Senol Yavuz; Michel Pompeu Barros de Oliveira Sá; William L Baker; Jae-Sik Jang; Mengqi Gong; Umberto Benedetto; Pascal M Dohmen; Fabrizio D'Ascenzo; Abhishek J Deshmukh; Giuseppe Biondi-Zoccai; Hugh Calkins; Gregg W Stone; Integrated Meta-Analysis Of Cardiac Surgery And Cardiology-Group Imcsc-Group Journal: Med Sci Monit Basic Res Date: 2017-03-17