Akikazu Sakudo1, Koichi Baba, Kazuyoshi Ikuta. 1. Department of Virology, Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. sakudo@med.u-ryukyu.ac.jp
Abstract
BACKGROUND: Human influenza A and B viruses cause severe seasonal respiratory tract infections, especially in infants and young children. Influenza A and B viruses have been reported to produce different symptoms and/or severity in infected patients, although these remain inconclusive. OBJECTIVES AND STUDY DESIGN: In this study, non-invasive visible and near-infrared (Vis-NIR) spectroscopy was used for comparative analysis of the inflammatory response to influenza A and B virus infections, by measuring changes in water peak (970 nm) spectra collected from patient nasal mucosal regions. RESULTS: The results suggested that infection with influenza B virus induced more severe inflammatory responses in the nasal mucosal region than influenza A virus. CONCLUSIONS: These are the first data showing different inflammatory responses to influenza A and B viruses at the sites of virus infection.
BACKGROUND:Humaninfluenza A and B viruses cause severe seasonal respiratory tract infections, especially in infants and young children. Influenza A and B viruses have been reported to produce different symptoms and/or severity in infectedpatients, although these remain inconclusive. OBJECTIVES AND STUDY DESIGN: In this study, non-invasive visible and near-infrared (Vis-NIR) spectroscopy was used for comparative analysis of the inflammatory response to influenza A and B virus infections, by measuring changes in water peak (970 nm) spectra collected from patient nasal mucosal regions. RESULTS: The results suggested that infection with influenza B virus induced more severe inflammatory responses in the nasal mucosal region than influenza A virus. CONCLUSIONS: These are the first data showing different inflammatory responses to influenza A and B viruses at the sites of virus infection.
Authors: Stephen S H Huang; David Banner; Stephane G Paquette; Alberto J Leon; Alyson A Kelvin; David J Kelvin Journal: J Gen Virol Date: 2014-07-02 Impact factor: 3.891
Authors: Philippe Noriel Q Pascua; Bindumadhav M Marathe; Andrew J Burnham; Peter Vogel; Richard J Webby; Robert G Webster; Elena A Govorkova Journal: PLoS One Date: 2016-07-28 Impact factor: 3.240