OBJECTIVE: The effect of statins on coronary artery plaque features beyond stenosis severity is not known. Coronary CT angiography (CCTA) is a novel non-invasive method that permits direct visualization of coronary atherosclerotic features, including plaque composition. We evaluated the association of statin use to coronary plaque composition type in patients without known coronary artery disease (CAD) undergoing CCTA. METHODS: From consecutive individuals, we identified 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) with no known CAD and available statin use status. We studied the relationship between statin use and the presence and extent of specific plaque composition types, which was graded as non-calcified (NCP), mixed (MP), or calcified (CP) plaque. RESULTS: The mean age was 59 ± 11 (55% male). Compared to the individuals not taking statins, those taking statins had higher prevalence of risk factors and obstructive CAD. In multivariable analyses, statin use was associated with increased the presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27-1.68), p < 0.001] and CP (OR 1.54, 95% CI 1.36-1.74, p < 0.001), but not NCP (OR 1.11, 95% CI 0.96-1.29, p = 0.1). Further, in multivariable analyses, statin use was associated with increasing numbers of coronary segments possessing MP (OR 1.52, 95% CI 1.34-1.73, p < 0.001) and CP (OR 1.52, 95% CI 1.36-1.70, p < 0.001), but not coronary segments with NCP (OR 1.09, 95% CI 0.94-1.25, p = 0.2). CONCLUSION: Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium. The longitudinal effect of statins on coronary plaque composition warrants further investigation.
OBJECTIVE: The effect of statins on coronary artery plaque features beyond stenosis severity is not known. Coronary CT angiography (CCTA) is a novel non-invasive method that permits direct visualization of coronary atherosclerotic features, including plaque composition. We evaluated the association of statin use to coronary plaque composition type in patients without known coronary artery disease (CAD) undergoing CCTA. METHODS: From consecutive individuals, we identified 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) with no known CAD and available statin use status. We studied the relationship between statin use and the presence and extent of specific plaque composition types, which was graded as non-calcified (NCP), mixed (MP), or calcified (CP) plaque. RESULTS: The mean age was 59 ± 11 (55% male). Compared to the individuals not taking statins, those taking statins had higher prevalence of risk factors and obstructive CAD. In multivariable analyses, statin use was associated with increased the presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27-1.68), p < 0.001] and CP (OR 1.54, 95% CI 1.36-1.74, p < 0.001), but not NCP (OR 1.11, 95% CI 0.96-1.29, p = 0.1). Further, in multivariable analyses, statin use was associated with increasing numbers of coronary segments possessing MP (OR 1.52, 95% CI 1.34-1.73, p < 0.001) and CP (OR 1.52, 95% CI 1.36-1.70, p < 0.001), but not coronary segments with NCP (OR 1.09, 95% CI 0.94-1.25, p = 0.2). CONCLUSION: Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium. The longitudinal effect of statins on coronary plaque composition warrants further investigation.
Authors: Szilard Voros; Sarah Rinehart; Zhen Qian; Gustavo Vazquez; Hunt Anderson; Laura Murrieta; Charles Wilmer; Harold Carlson; Kenneth Taylor; William Ballard; Dimitri Karmpaliotis; Anna Kalynych; Charles Brown Journal: JACC Cardiovasc Interv Date: 2011-02 Impact factor: 11.195
Authors: M Schartl; W Bocksch; D H Koschyk; W Voelker; K R Karsch; J Kreuzer; D Hausmann; S Beckmann; M Gross Journal: Circulation Date: 2001-07-24 Impact factor: 29.690
Authors: James K Min; Allison Dunning; Fay Y Lin; Stephan Achenbach; Mouaz H Al-Mallah; Daniel S Berman; Matthew J Budoff; Filippo Cademartiri; Tracy Q Callister; Hyuk-Jae Chang; Victor Cheng; Kavitha M Chinnaiyan; Benjamin Chow; Augustin Delago; Martin Hadamitzky; Jorg Hausleiter; Ronald P Karlsberg; Philipp Kaufmann; Erica Maffei; Khurram Nasir; Michael J Pencina; Gilbert L Raff; Leslee J Shaw; Todd C Villines Journal: J Cardiovasc Comput Tomogr Date: 2011-02-01
Authors: Bennett G Childs; Cheng Zhang; Fahad Shuja; Ines Sturmlechner; Shawn Trewartha; Raul Fierro Velasco; Darren Baker; Hu Li; Jan M van Deursen Journal: Nat Aging Date: 2021-08-02
Authors: Dustin M Thomas; Sanjay Divakaran; Todd C Villines; Khurram Nasir; Nishant R Shah; Ahmad M Slim; Ron Blankstein; Michael K Cheezum Journal: Curr Cardiovasc Imaging Rep Date: 2015
Authors: Yun-Kyeong Cho; Chang-Wook Nam; Bon-Kwon Koo; Joshua Schulman-Marcus; Bríain Ó Hartaigh; Heidi Gransar; Yao Lu; Stephan Achenbach; Mouaz Al-Mallah; Daniele Andreini; Jeroen J Bax; Matthew J Budoff; Filippo Cademartiri; Tracy Q Callister; Hyuk-Jae Chang; Kavitha Chinnaiyan; Benjamin J W Chow; Ricardo C Cury; Augustin Delago; Gudrun Feuchtner; Martin Hadamitzky; Jörg Hausleiter; Philipp A Kaufmann; Yong-Jin Kim; Jonathon Leipsic; Erica Maffei; Hugo Marques; Gianluca Pontone; Gilbert L Raff; Ronen Rubinshtein; Leslee J Shaw; Todd C Villines; Daniel S Berman; Erica C Jones; Jessica M Peña; Fay Y Lin; James K Min Journal: PLoS One Date: 2018-12-12 Impact factor: 3.240